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    pgi glucose-6-phosphate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948535, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pgi
    Official Full Name
    glucose-6-phosphate isomerase
    Primary source
    ECOCYC:EG10702
    Locus tag
    b4025
    See related
    ASAP:ABE-0013163
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4017
    Summary
    Also called phosphoglucose isomerase. [More information is available at EcoGene: EG10702]. [More information is available at EcoCyc: EG10702].
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    Genomic context

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    Sequence:
    NC_000913.3 (4233758..4235407)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF3811 domain-containing protein YjbD Neighboring gene aspartate kinase III Neighboring gene uncharacterized protein YjbE Neighboring gene lipoprotein YjbF Neighboring gene capsule biosynthesis GfcC family protein YjbG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. INTRACELLULAR PH EFFECT UPON PHOSPHOGLUCOSE ISOMERASE IN ESCHERICHIA COLI. KLUNGSOEYR L, et al. Biochim Biophys Acta, 1964 Nov 22. PMID 14249126
    2. Gene expression patterns for metabolic pathway in pgi knockout Escherichia coli with and without phb genes based on RT-PCR. Kabir MM, et al. J Biotechnol, 2003 Oct 9. PMID 14511906
    3. Multiple Optimal Phenotypes Overcome Redox and Glycolytic Intermediate Metabolite Imbalances in Escherichia coli pgi Knockout Evolutions. McCloskey D, et al. Appl Environ Microbiol, 2018 Oct 1. PMID 30054360, Free PMC Article
    4. A novel bioluminescent bacterial biosensor using the highly specific oxidative stress-inducible pgi gene. Niazi JH, et al. Biosens Bioelectron, 2008 Dec 1. PMID 18657410
    5. Nature of the effector of catabolite repression of beta-galactosidase in Escherichia coli. Loomis WF Jr, et al. J Bacteriol, 1966 Jul. PMID 5328748, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pgi knockout exhibited an 80% drop in growth rate that was largely recovered in eight replicate, but phenotypically distinct, cultures after undergoing adaptive laboratory evolution.
      Title: Multiple Optimal Phenotypes Overcome Redox and Glycolytic Intermediate Metabolite Imbalances in Escherichia coli pgi Knockout Evolutions.
    2. pgi transcription and enzymatic activity are induced under oxidative stress, and is regulated by the SoxRS system.
      Title: Activation of glucose transport under oxidative stress in Escherichia coli.
    3. transformation with different pET-plasmids containing archaeal or bacterial pgi, cpgi or pgi/pmi genes from the three known PGI families (PGI, PGI/PMI, cPGI) restored growth
      Title: Escherichia coli phosphoglucose isomerase can be substituted by members of the PGI family, the PGI/PMI family, and the cPGI family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbohydrate derivative binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-6-phosphate isomerase
    NP_418449.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4233758..4235407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418449.1 glucose-6-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418449.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EC36
      Conserved Domains (1) summary
      PRK00179
      Location:2 → 549
      pgi; glucose-6-phosphate isomerase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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