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    amiB N-acetylmuramoyl-L-alanine amidase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948683, updated on 3-Dec-2024

    Summary

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    Official Symbol
    amiB
    Official Full Name
    N-acetylmuramoyl-L-alanine amidase B
    Primary source
    ECOCYC:EG11363
    Locus tag
    b4169
    See related
    ASAP:ABE-0013653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4165; yjeD
    Summary
    First 22 aa are predicted to be a type I signal peptide. [More information is available at EcoGene: EG11363]. Escherichia coli contains three N-acetylmuramyl-L-alanine amidases named AmiA, B, and C involved in cell division by splitting the murein septum. [More information is available at EcoCyc: EG11363].
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    Genomic context

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    Sequence:
    NC_000913.3 (4396065..4397402)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YjeV Neighboring gene epoxyqueuosine reductase Neighboring gene NAD(P)HX epimerase/NAD(P)HX dehydratase Neighboring gene N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit Neighboring gene DNA mismatch repair protein MutL Neighboring gene tRNA dimethylallyltransferase Neighboring gene RNA-binding protein Hfq

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conformational switch controls cell wall-remodelling enzymes required for bacterial cell division. Yang DC, et al. Mol Microbiol, 2012 Aug. PMID 22715947, Free PMC Article
    2. A fail-safe mechanism in the septal ring assembly pathway generated by the sequential recruitment of cell separation amidases and their activators. Peters NT, et al. J Bacteriol, 2011 Sep. PMID 21764913, Free PMC Article
    3. Nonconserved segment of the MutL protein from Escherichia coli K-12 and Salmonella typhimurium. Tsui HT, et al. Nucleic Acids Res, 1992 May 11. PMID 1594459, Free PMC Article
    4. Activity of three murein hydrolases during the cell division cycle of Escherichia coli K-12 as measured in toluene-treated cells. Beck BD, et al. J Bacteriol, 1976 Jun. PMID 780345, Free PMC Article
    5. The mutL repair gene of Escherichia coli K-12 forms a superoperon with a gene encoding a new cell-wall amidase. Tsui HC, et al. Mol Microbiol, 1994 Jan. PMID 7511774

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poorly regulated amiB mutants were isolated encoding lytic AmiB variants with elevated basal PG hydrolase activities in vitro.
      Title: A conformational switch controls cell wall-remodelling enzymes required for bacterial cell division.
    2. The authors report that AmiB and EnvC are recruited to division sites independently of one another. The same is also true for AmiC and NlpD.
      Title: A fail-safe mechanism in the septal ring assembly pathway generated by the sequential recruitment of cell separation amidases and their activators.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylmuramoyl-L-alanine amidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylmuramoyl-L-alanine amidase B
    NP_418590.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4396065..4397402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418590.1 N-acetylmuramoyl-L-alanine amidase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418590.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5ZBW8
      Conserved Domains (1) summary
      PRK10431
      Location:1 → 445
      PRK10431; N-acetylmuramoyl-l-alanine amidase II; Provisional
    Nucleotide Protein
    Heading Accession and Version

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