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    mpl UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948752, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mpl
    Official Full Name
    UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
    Primary source
    ECOCYC:EG12440
    Locus tag
    b4233
    See related
    ASAP:ABE-0013847
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4228; tpl; yjfG
    Summary
    RpoS regulon. [More information is available at EcoGene: EG12440]. The mpl gene encodes UDP-N-acetylmuramate:L-alanyl--D-glutamyl-meso-diaminopimelate ligase, which acts in murein recycling by allowing ligation of the tripeptide L-Ala-D-Glu-mesoA2pm with UDP-MurNAc and reincorporation into peptidoglycan. [More information is available at EcoCyc: EG12440].
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    Genomic context

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    Sequence:
    NC_000913.3 (4455785..4457158)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactofuranose ABC transporter putative membrane subunit YtfT Neighboring gene galactofuranose ABC transporter putative membrane subunit YjtF Neighboring gene fructose-1,6-bisphosphatase 1 Neighboring gene putative ribosome biogenesis factor YjgA Neighboring gene metalloprotease subunit TldE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan turnover IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan turnover IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
    NP_418654.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4455785..4457158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418654.1 UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418654.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A829LA83
      Conserved Domains (1) summary
      TIGR01081
      Location:2 → 450
      mpl; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
    Nucleotide Protein
    Heading Accession and Version

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