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    tldE metalloprotease subunit TldE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948750, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tldE
    Official Full Name
    metalloprotease subunit TldE
    Primary source
    ECOCYC:EG10741
    Locus tag
    b4235
    See related
    ASAP:ABE-0013854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4230; mcb; pmbA
    Summary
    TldD and/or TldE act as a protease that is involved in sensitivity to DNA gyrase inhibitor LetD/CcdB (encoded by the F plasmid) by effecting degradation of the F plasmid-encoded LetD inhibitor, LetA/CcdA . [More information is available at EcoCyc: EG10741].
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    Genomic context

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    Sequence:
    NC_000913.3 (4457959..4459311)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase Neighboring gene putative ribosome biogenesis factor YjgA Neighboring gene pseudo Neighboring gene anaerobic ribonucleoside-triphosphate reductase activating protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of the stationary phase-induced mcb operon promoter in Escherichia coli. Mao W, et al. Mol Microbiol, 1998 Jan. PMID 9484896
    2. Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance. Lomovskaya O, et al. Antimicrob Agents Chemother, 1996 Apr. PMID 8849229, Free PMC Article
    3. Molecular characterization of pmbA, an Escherichia coli chromosomal gene required for the production of the antibiotic peptide MccB17. Rodríguez-Sáinz MC, et al. Mol Microbiol, 1990 Nov. PMID 2082149
    4. Factors influencing preferential utilization of RNA polymerase containing sigma-38 in stationary-phase gene expression in Escherichia coli. Kim EY, et al. J Microbiol, 2004 Jun. PMID 15357303
    5. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    metalloprotease subunit TldE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4457959..4459311
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418656.1 metalloprotease subunit TldE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418656.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6ZL35
      Conserved Domains (1) summary
      PRK11040
      Location:5 → 450
      PRK11040; peptidase PmbA; Provisional
    Nucleotide Protein
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