U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lptF lipopolysaccharide transport system protein LptF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948795, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lptF
    Official Full Name
    lipopolysaccharide transport system protein LptF
    Primary source
    ECOCYC:G7888
    Locus tag
    b4261
    See related
    ASAP:ABE-0013958
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4254; yjgP
    Summary
    LptF (YjgP) is an inner membrane protein with six predicted transmembrane domains. [More information is available at EcoCyc: G7888].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4486218..4487318)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YtgB Neighboring gene protein YtgA Neighboring gene lipopolysaccharide transport system protein LptG Neighboring gene DUF853 domain-containing protein YjgR Neighboring gene DNA-binding transcriptional dual regulator IdnR

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function. Simpson BW, et al. mBio, 2016 Oct 18. PMID 27795402, Free PMC Article
    2. Structural basis of lipopolysaccharide extraction by the LptB(2)FGC complex. Li Y, et al. Nature, 2019 Mar. PMID 30894744, Free PMC Article
    3. Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides. Narita S, et al. FEBS Lett, 2009 Jul 7. PMID 19500581
    4. Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Sherman DJ, et al. Science, 2018 Feb 16. PMID 29449493, Free PMC Article
    5. Experimental determination and system level analysis of essential genes in Escherichia coli MG1655. Gerdes SY, et al. J Bacteriol, 2003 Oct. PMID 13129938, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, these data identify a specific binding site in LptB for the coupling helices of LptFG that is responsible for coupling of ATP hydrolysis by LptB with LptFG function to achieve lipopolysaccharide extraction.
      Title: Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function.
    2. both LptF and LptG formed a complex with LptB.
      Title: Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Gram-negative-bacterium-type cell outer membrane assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in lipopolysaccharide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipopolysaccharide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lipopolysaccharide transport system protein LptF
    NP_418682.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4486218..4487318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418682.1 lipopolysaccharide transport system protein LptF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418682.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MX13
      Conserved Domains (1) summary
      PRK15120
      Location:1 → 366
      PRK15120; lipopolysaccharide ABC transporter permease LptF; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.