U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tar methyl-accepting chemotaxis protein Tar [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946399, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tar
    Official Full Name
    methyl-accepting chemotaxis protein Tar
    Primary source
    ECOCYC:EG10988
    Locus tag
    b1886
    See related
    ASAP:ABE-0006290
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cheM; ECK1887
    Summary
    Tar senses maltose indirectly through periplasmic maltose binding protein. [More information is available at EcoGene: EG10988]. Tar is a chemoreceptor which senses aspartate and exists as a functional homodimer . [More information is available at EcoCyc: EG10988].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1971030..1972691, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein methyltransferase Neighboring gene methyl-accepting chemotaxis protein Tap Neighboring gene chemotaxis protein CheW Neighboring gene chemotaxis protein CheA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Attractant signaling by an aspartate chemoreceptor dimer with a single cytoplasmic domain. Gardina PJ, et al. Science, 1996 Oct 18. PMID 8832892
    2. Effects of adaptation in maintaining high sensitivity over a wide range of backgrounds for Escherichia coli chemotaxis. Mello BA, et al. Biophys J, 2007 Apr 1. PMID 17208965, Free PMC Article
    3. Tuning a bacterial chemoreceptor with protein-membrane interactions. Draheim RR, et al. Biochemistry, 2006 Dec 12. PMID 17144658
    4. The HAMP domain structure implies helix rotation in transmembrane signaling. Hulko M, et al. Cell, 2006 Sep 8. PMID 16959572
    5. Mutationally altered signal output in the Nart (NarX-Tar) hybrid chemoreceptor. Ward SM, et al. J Bacteriol, 2006 Jun. PMID 16707686, Free PMC Article

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blue light is a universal signal for Escherichia coli chemoreceptors.
      Title: Blue Light Is a Universal Signal for Escherichia coli Chemoreceptors.
    2. Thus, the proportion of polypeptide chain that is locally and presumably transiently disordered is a structural feature of cytoplasmic domain dynamics that varies with functional region and modification-induced signaling state.
      Title: Bacterial Chemoreceptor Dynamics: Helical Stability in the Cytoplasmic Domain Varies with Functional Segment and Adaptational Modification.
    3. There is a differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues.
      Title: Differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues.
    4. the Tar(FO) modules demonstrate that trimerized signaling tips self-associate, bind CheA and CheW, and facilitate conversion of CheA to an active conformation.
      Title: Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation.
    5. Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the Tar chemoreceptor.
      Title: Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the TarEc chemoreceptor.
    6. Such inversion is enabled by opposing pH sensing by the two major chemoreceptors, Tar and Tsr, such that the relative strength of the response is modulated by adaptive receptor methylation.
      Title: Opposite responses by different chemoreceptors set a tunable preference point in Escherichia coli pH taxis.
    7. Here we report the overexpression system for aCB2 in Escherichia coli C43(DE3) facilitated by two fusion partners: Mistic and TarCF, a C-terminal fragment of the bacterial chemosensory transducer Tar at the C-terminal of the CB2 open reading frame region.
      Title: Mistic and TarCF as fusion protein partners for functional expression of the cannabinoid receptor 2 in Escherichia coli.
    8. characterization of structural features of carboxyl-terminal 40 residues of Tar; identifed carboxyl-terminal linker between receptor body and the pentapeptide is an unstructured, disordered segment that can serve as a flexible arm and enzyme tether
      Title: Direct evidence that the carboxyl-terminal sequence of a bacterial chemoreceptor is an unstructured linker and enzyme tether.
    9. Ligand specificity is determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar
      Title: Ligand specificity determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar.
    10. Tar molecules with the cytoplasmic methylation and kinase control domains of Tsr still sensed phenol as an attractant.
      Title: Phenol sensing by Escherichia coli chemoreceptors: a nonclassical mechanism.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of chemical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of post-translational protein modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of methyl accepting chemotaxis protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of methyl accepting chemotaxis protein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    methyl-accepting chemotaxis protein Tar

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1971030..1972691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416400.1 methyl-accepting chemotaxis protein Tar [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416400.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L5H8Z7
      Conserved Domains (1) summary
      PRK15048
      Location:1 → 553
      PRK15048; methyl-accepting chemotaxis protein II; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.