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    gmm GDP-mannose mannosyl hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946559, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gmm
    Official Full Name
    GDP-mannose mannosyl hydrolase
    Primary source
    ECOCYC:EG11789
    Locus tag
    b2051
    See related
    ASAP:ABE-0006796
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2045; nudD; wcaH; yefC
    Summary
    Nudix hydrolase. [More information is available at EcoGene: EG11789]. GDP-mannose mannosyl hydrolase (GDPMH) is able to hydrolyze both GDP-mannose and GDP-glucose. [More information is available at EcoCyc: EG11789].
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    Genomic context

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    Sequence:
    NC_000913.3 (2125743..2126222, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphomannomutase Neighboring gene mannose-1-phosphate guanylyltransferase Neighboring gene colanic acid biosynthesis fucosyltransferase WcaI Neighboring gene GDP-L-fucose synthase Neighboring gene GDP-mannose 4,6-dehydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for substrate selectivity and specificity by an LPS biosynthetic enzyme. Zou Y, et al. Biochemistry, 2007 Apr 10. PMID 17371001
    2. A novel GDP-mannose mannosyl hydrolase shares homology with the MutT family of enzymes. Frick DN, et al. J Biol Chem, 1995 Oct 13. PMID 7592609
    3. GDP-mannose mannosyl hydrolase catalyzes nucleophilic substitution at carbon, unlike all other Nudix hydrolases. Legler PM, et al. Biochemistry, 2000 Jul 25. PMID 10913267
    4. Kinetic and magnetic resonance studies of the role of metal ions in the mechanism of Escherichia coli GDP-mannose mannosyl hydrolase, an unusual nudix enzyme. Legler PM, et al. Biochemistry, 2002 Apr 9. PMID 11926828
    5. Evidence for effect of random genetic drift on G+C content after lateral transfer of fucose pathway genes to Escherichia coli K-12. Aoyama K, et al. Mol Biol Evol, 1994 Nov. PMID 7815923

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GDP-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose mannosyl hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose mannosyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GDP-mannose mannosyl hydrolase
    NP_416555.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2125743..2126222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416555.2 GDP-mannose mannosyl hydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416555.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0K4TWI1, A0A1X3JE67, A0A7U9QEV0, A0AAN4QN65, G1UGG6
      Conserved Domains (1) summary
      PRK15434
      Location:1 → 159
      PRK15434; GDP-mannose mannosyl hydrolase
    Nucleotide Protein
    Heading Accession and Version

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