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    ccmA cytochrome c maturation protein A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946714, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ccmA
    Official Full Name
    cytochrome c maturation protein A
    Primary source
    ECOCYC:EG12059
    Locus tag
    b2201
    See related
    ASAP:ABE-0007279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2193; yejW
    Summary
    CcmA is the ATP-binding component of the CcmABC protoheme IX ABC transporter. [More information is available at EcoCyc: EG12059].
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    Genomic context

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    Sequence:
    NC_000913.3 (2297021..2297644, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene periplasmic nitrate reductase cytochrome c protein Neighboring gene periplasmic nitrate reductase cytochrome c550 protein Neighboring gene ferredoxin-type protein NapH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytochrome c maturation: a complex pathway for a simple task? Thöny-Meyer L. Biochem Soc Trans, 2002 Aug. PMID 12196152
    2. Transmembrane heme delivery systems. Goldman BS, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560218, Free PMC Article
    3. Avoidance of the cytochrome c biogenesis system by periplasmic CXXCH motifs. Mavridou DA, et al. Biochem Soc Trans, 2008 Dec. PMID 19021509
    4. Control of DegP-dependent degradation of c-type cytochromes by heme and the cytochrome c maturation system in Escherichia coli. Gao T, et al. J Bacteriol, 2007 Sep. PMID 17616605, Free PMC Article
    5. Axial coordination of heme in ferric CcmE chaperone characterized by EPR spectroscopy. García-Rubio I, et al. Biophys J, 2007 Feb 15. PMID 17142277, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role for CcmAB is suggested in the handling of heme by CcmE, which is chemically complex and involves an unusual histidine-heme covalent bond.
      Title: Loss of ATP hydrolysis activity by CcmAB results in loss of c-type cytochrome synthesis and incomplete processing of CcmE.
    2. Expression of CcmA facilitates formation of the CcmA2B1C1 complex and ATP-dependent release of holoCcmE.
      Title: ABC transporter-mediated release of a haem chaperone allows cytochrome c biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type heme transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytochrome c biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytochrome c biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytochrome complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytochrome complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c maturation protein A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2297021..2297644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416705.2 cytochrome c maturation protein A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416705.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0C2EIE7, A0A0D8VKH2, A0A0E2L5P7, A0A0L6Y146, A0A2H4TXG0, A0A376FYE5, A0A377EMA5, A0A776L792, A0A7I0L1T2, A0A828U6I4, A0A8H9VNS5, A0A8S7TYD2, A0AAE4X472, A7ZP23, B7UFL4, S1PZA9
      Conserved Domains (1) summary
      PRK13538
      Location:3 → 203
      PRK13538; cytochrome c biogenesis heme-transporting ATPase CcmA
    Nucleotide Protein
    Heading Accession and Version

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