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    eptA phosphoethanolamine transferase EptA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948629, updated on 3-Dec-2024

    Summary

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    Official Symbol
    eptA
    Official Full Name
    phosphoethanolamine transferase EptA
    Primary source
    ECOCYC:EG11613
    Locus tag
    b4114
    See related
    ASAP:ABE-0013469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4107; yjdB
    Summary
    EptA co-localizes with ZipA. [More information is available at EcoGene: EG11613]. The YjdB protein can be found in the membrane in a complex with ZipA and an unidentified 24 kDa protein . [More information is available at EcoCyc: EG11613].
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    Genomic context

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    Sequence:
    NC_000913.3 (4333947..4335590, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene osmolyte:H(+) symporter ProP Neighboring gene small regulatory membrane protein PmrR Neighboring gene sensor histidine kinase BasS Neighboring gene DNA-binding transcriptional dual regulator BasR Neighboring gene arginine:agmatine antiporter Neighboring gene DNA-binding transcriptional activator AdiY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases. Purcell AB, et al. J Bacteriol, 2022 Feb 15. PMID 34843376, Free PMC Article
    2. Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada. Tijet N, et al. PLoS One, 2017. PMID 28678874, Free PMC Article
    3. Abstracts of the 7th Conference of the International Endotoxin Society. Washington, DC, USA. 18-21 July 2002. . J Endotoxin Res, 2002. PMID 12184950
    4. Ovipleistophora gen. n., a new genus for Pleistophora mirandellae-like microsporidia. Pekkarinen M, et al. Dis Aquat Organ, 2002 Mar 11. PMID 12005235
    5. Novel members of the two-component signal transduction genes in Escherichia coli. Nagasawa S, et al. J Biochem, 1993 Sep. PMID 8282725

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases.
      Title: Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases.
    2. Data suggest that the plasmid-encoded phosphoethanolamine transferase MCR-1-harboring plasmid is playing an important role in spreading this mechanism of resistance to polymyxins.
      Title: Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada.
    3. YjdB, which co-localizes with the ZipA protein, is involved in cell division
      Title: Protein complexes of the Escherichia coli cell envelope.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables phosphotransferase activity, phosphate group as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotransferase activity, phosphate group as acceptor TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lipopolysaccharide core region biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphoethanolamine transferase EptA
    NP_418538.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4333947..4335590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418538.2 phosphoethanolamine transferase EptA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418538.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1PLQ4
      Conserved Domains (1) summary
      PRK11598
      Location:2 → 546
      PRK11598; putative metal dependent hydrolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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