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    nhaR DNA-binding transcriptional activator NhaR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944757, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nhaR
    Official Full Name
    DNA-binding transcriptional activator NhaR
    Primary source
    ECOCYC:EG11078
    Locus tag
    b0020
    See related
    ASAP:ABE-0000072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    antO; ECK0021; yaaB
    Summary
    nhaR lacks an obvious promoter and may be expressed via nhaA readthrough. [More information is available at EcoGene: EG11078].
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    Genomic context

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    Sequence:
    NC_000913.3 (18715..19620)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulatory protein MokC Neighboring gene ncRNA Neighboring gene Na(+):H(+) antiporter NhaA Neighboring gene IS1 family protein InsB Neighboring gene IS1 family protein InsA Neighboring gene 30S ribosomal subunit protein S20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes. Novichkov PS, et al. Nucleic Acids Res, 2010 Jan. PMID 19884135, Free PMC Article
    2. The Na+-specific interaction between the LysR-type regulator, NhaR, and the nhaA gene encoding the Na+/H+ antiporter of Escherichia coli. Carmel O, et al. EMBO J, 1997 Oct 1. PMID 9312050, Free PMC Article
    3. NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli. Rahav-Manor O, et al. J Biol Chem, 1992 May 25. PMID 1316901
    4. Structure of the DNA distal to the gene for ribosomal protein S20 in Escherichia coli K12: presence of a strong terminator and an IS1 element. Mackie GA. Nucleic Acids Res, 1986 Sep 11. PMID 2429258, Free PMC Article
    5. A single amino acid substitution (Glu134-->Ala) in NhaR1 increases the inducibility by Na+ of the product of nhaA, a Na+/H+ antiporter gene in Escherichia coli. Carmel O, et al. EMBO J, 1994 Apr 15. PMID 8168494, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator NhaR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      18715..19620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414561.1 DNA-binding transcriptional activator NhaR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414561.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0E0Y5G8, A0A0H3MHP0, A0A0H3PV63, A0A1X3IC01, A0A1X3J7X1, A0A1X3JN52, A0A2A2XG39, A0A6M0JDI3, A0A8E0FJN2, A0A9P2IB70, A0AA35AHG6, A0AAN1S1D9, A0AAN3MAT3, A0AAN3V2P6, B7L4E1, B7N7P1, C3TRI3, J7QWQ5, W1F7Y9
      Conserved Domains (1) summary
      PRK11062
      Location:3 → 298
      nhaR; transcriptional activator NhaR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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