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    trmO tRNA m(6)t(6)A37 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949112, updated on 17-Dec-2024

    Summary

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    Official Symbol
    trmO
    Official Full Name
    tRNA m(6)t(6)A37 methyltransferase
    Primary source
    ECOCYC:EG11503
    Locus tag
    b0195
    See related
    ASAP:ABE-0000661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0195; tsaA; yaeB
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    Genomic context

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    Sequence:
    NC_000913.3 (218887..219594, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase C92 family protein YaeF Neighboring gene proline--tRNA ligase Neighboring gene sensor lipoprotein RcsF Neighboring gene L-methionine/D-methionine ABC transporter membrane anchored binding protein Neighboring gene L-methionine/D-methionine ABC transporter membrane subunit Neighboring gene L-methionine/D-methionine ABC transporter ATP binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleotide sequence of a threonine transfer ribonucleic acid from Escherichia coli. Clarke L, et al. J Biol Chem, 1974 Nov 10. PMID 4608712
    2. Nucleotide sequence of tRNA(Thr1) of Escherichia coli and of the gene (thrV) that encodes it. Komine Y, et al. Nucleic Acids Res, 1992 Aug 11. PMID 1380693, Free PMC Article
    3. Identification, cloning, and characterization of rcsF, a new regulator gene for exopolysaccharide synthesis that suppresses the division mutation ftsZ84 in Escherichia coli K-12. Gervais FG, et al. J Bacteriol, 1992 Dec. PMID 1459951, Free PMC Article
    4. The methyl group of the N6-methyl-N6-threonylcarbamoyladenosine in tRNA of Escherichia coli modestly improves the efficiency of the tRNA. Qian Q, et al. J Bacteriol, 1998 Apr. PMID 9537379, Free PMC Article
    5. Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. Kimura S, et al. Nucleic Acids Res, 2014 Aug. PMID 25063302, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study demonstrates that tsaA is found to be yaeB which is responsible for N6-methylation of N(6)-methyl-threonylcarbamoyl adenosine (m6t6A) in tRNAThr.
      Title: Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA m(6)t(6)A37 methyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      218887..219594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414737.1 tRNA m(6)t(6)A37 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414737.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9ABJ7
      Conserved Domains (2) summary
      COG1720
      Location:3 → 157
      TsaA; tRNA (Thr-GGU) A37 N-methylase [Translation, ribosomal structure and biogenesis]
      pfam18389
      Location:159 → 223
      TrmO_C; TrmO C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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