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    yafO ribosome-dependent mRNA interferase toxin YafO [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944916, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yafO
    Official Full Name
    ribosome-dependent mRNA interferase toxin YafO
    Primary source
    ECOCYC:G6117
    Locus tag
    b0233
    See related
    ASAP:ABE-0000795
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0234
    Summary
    LexA regulon. dinB-yafNOP operon. [More information is available at EcoGene: EG13152]. Polar dinB mutations affecting the dinB-yafN-yafO-yafP operon reduce spontaneous mutagenesis . [More information is available at EcoCyc: G6117].
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    Genomic context

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    Sequence:
    NC_000913.3 (252301..252699)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase IV Neighboring gene antitoxin YafN Neighboring gene putative N-acetyltransferase YafP Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary crystallographic studies of the YafN-YafO complex from Escherichia coli. Zhang F, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Aug 1. PMID 22869116, Free PMC Article
    2. Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Courcelle J, et al. Genetics, 2001 May. PMID 11333217, Free PMC Article
    3. The dinB operon and spontaneous mutation in Escherichia coli. McKenzie GJ, et al. J Bacteriol, 2003 Jul. PMID 12813093, Free PMC Article
    4. Genomic changes arising in long-term stab cultures of Escherichia coli. Faure D, et al. J Bacteriol, 2004 Oct. PMID 15375124, Free PMC Article
    5. An SOS-regulated type 2 toxin-antitoxin system. Singletary LA, et al. J Bacteriol, 2009 Dec. PMID 19837801, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosomal large subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SOS response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SOS response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome-dependent mRNA interferase toxin YafO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      252301..252699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414768.1 ribosome-dependent mRNA interferase toxin YafO [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414768.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q5DXZ2
      Conserved Domains (1) summary
      PRK09885
      Location:1 → 132
      PRK09885; type II toxin-antitoxin system YafO family toxin
    Nucleotide Protein
    Heading Accession and Version

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