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    secF Sec translocon accessory complex subunit SecF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949120, updated on 3-Dec-2024

    Summary

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    Official Symbol
    secF
    Official Full Name
    Sec translocon accessory complex subunit SecF
    Primary source
    ECOCYC:EG10940
    Locus tag
    b0409
    See related
    ASAP:ABE-0001419
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0403
    Summary
    SecYEG complex interacts with SecDFyajC to form a hexameric holocomplex. [More information is available at EcoGene: EG10940]. SecD/SecF/YajC and YidC are all components of the Sec protein secretion pathway. [More information is available at EcoCyc: EG10940].
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    Genomic context

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    Sequence:
    NC_000913.3 (429505..430476)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Sec translocon accessory complex subunit YajC Neighboring gene Sec translocon accessory complex subunit SecD Neighboring gene HNH nuclease family protein YajD Neighboring gene nucleoside-specific channel-forming protein Tsx

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein translocation in vitro: biochemical characterization of genetically defined translocation components. Fandl J, et al. J Bioenerg Biomembr, 1990 Jun. PMID 2167893
    2. Different regions of the nonconserved large periplasmic domain of Escherichia coli YidC are involved in the SecF interaction and membrane insertase activity. Xie K, et al. Biochemistry, 2006 Nov 7. PMID 17073462
    3. Overproduction, purification and characterization of SecD and SecF, integral membrane components of the protein translocation machinery of Escherichia coli. Matsuyama S, et al. Biochim Biophys Acta, 1992 Jul 13. PMID 1633199
    4. The secD locus of E. coli codes for two membrane proteins required for protein export. Gardel C, et al. EMBO J, 1990 Dec. PMID 2249673, Free PMC Article
    5. SecF stabilizes SecD and SecY, components of the protein translocation machinery of the Escherichia coli cytoplasmic membrane. Sagara K, et al. J Bacteriol, 1994 Jul. PMID 8021192, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. two mutations confer cold-sensitive phenotype by inactivating the SecDF-YajC complex in protein translocation
      Title: Inactivation of protein translocation by cold-sensitive mutations in the yajC-secDF operon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein-transporting ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into membrane from inner side IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport by the Sec complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cell envelope Sec protein transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sec translocon accessory complex subunit SecF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      429505..430476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414943.1 Sec translocon accessory complex subunit SecF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414943.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3K0WGG0
      Conserved Domains (1) summary
      PRK13022
      Location:14 → 306
      secF; protein translocase subunit SecF
    Nucleotide Protein
    Heading Accession and Version

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