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    rlmI 23S rRNA m(5)C1962 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946691, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rlmI
    Official Full Name
    23S rRNA m(5)C1962 methyltransferase
    Primary source
    ECOCYC:G6501
    Locus tag
    b0967
    See related
    ASAP:ABE-0003272
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0958; yccW
    Summary
    RlmI is the methyltransferase responsible for methylation of 23S rRNA at the C5 position of the C1962 nucleotide. [More information is available at EcoCyc: G6501].
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    Genomic context

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    Sequence:
    NC_000913.3 (1028779..1029969, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative HspQ acetyl donor Neighboring gene heat shock protein HspQ Neighboring gene acylphosphatase Neighboring gene sulfur transfer protein TusE Neighboring gene modulator of FtsH protease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes. Sunita S, et al. J Mol Biol, 2008 Nov 14. PMID 18789337
    2. YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962. Purta E, et al. J Mol Biol, 2008 Nov 14. PMID 18786544
    3. YdgG (TqsA) controls biofilm formation in Escherichia coli K-12 through autoinducer 2 transport. Herzberg M, et al. J Bacteriol, 2006 Jan. PMID 16385049, Free PMC Article
    4. Protein abundance profiling of the Escherichia coli cytosol. Ishihama Y, et al. BMC Genomics, 2008 Feb 27. PMID 18304323, Free PMC Article
    5. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results report the crystal structure of the 23S rRNA:m5C methyltransferase RlmI refined at 2 A to a final R-factor of 0.194 (R(free)=0.242).
      Title: Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes.
    2. Results report the identity of a third E. coli m(5)C methyltransferase, YccW.
      Title: YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (cytosine) methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (cytosine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA base methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    23S rRNA m(5)C1962 methyltransferase
    NP_415487.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1028779..1029969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415487.4 23S rRNA m(5)C1962 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415487.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7T2IZ71
      Conserved Domains (1) summary
      PRK15128
      Location:1 → 396
      PRK15128; 23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI
    Nucleotide Protein
    Heading Accession and Version

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