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    clsC cardiolipin synthase C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947321, updated on 17-Dec-2024

    Summary

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    Official Symbol
    clsC
    Official Full Name
    cardiolipin synthase C
    Primary source
    ECOCYC:G6551
    Locus tag
    b1046
    See related
    ASAP:ABE-0003551
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1032; ymdC
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    Genomic context

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    Sequence:
    NC_000913.3 (1106355..1107776)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YmdA Neighboring gene 2'-O-acetyl-ADP-ribose deacetylase, regulator of RNase III activity Neighboring gene osmoregulated periplasmic glucans (OPG) biosynthesis protein C Neighboring gene osmoregulated periplasmic glucans biosynthesis protein G Neighboring gene osmoregulated periplasmic glucans biosynthesis protein H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The unusual substrate specificity of Escherichia coli cardiolipin synthase C does not require the product of the transcriptionally engaged ymdB gene. Sawasato K, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2024 Jun. PMID 38527666
    2. A second Escherichia coli protein with CL synthase activity. Guo D, et al. Biochim Biophys Acta, 2000 Jan 17. PMID 10634942
    3. Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. Tan BK, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 22988102, Free PMC Article
    4. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The unusual substrate specificity of Escherichia coli cardiolipin synthase C does not require the product of the transcriptionally engaged ymdB gene.
      Title: The unusual substrate specificity of Escherichia coli cardiolipin synthase C does not require the product of the transcriptionally engaged ymdB gene.
    2. Data indicate that the cardiolipin synthase DeltaclsABC mutant (clsA, clsB(ybhO) and clsC (ymdC))nlacks detectible cardiolipin (CL) regardless of growth phase or growth conditions.
      Title: Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiolipin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cardiolipin synthase C
    NP_415564.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1106355..1107776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415564.2 cardiolipin synthase C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415564.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0B0W257, A0A1E5M7Y4, A0A836NEV2, A0AAP9B3B9, B7NAS1
      Conserved Domains (2) summary
      cd09111
      Location:24 → 184
      PLDc_ymdC_like_1; Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins
      cd09113
      Location:250 → 469
      PLDc_ymdC_like_2; Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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