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    iraM anti-adaptor protein IraM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945729, updated on 3-Dec-2024

    Summary

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    Official Symbol
    iraM
    Official Full Name
    anti-adaptor protein IraM
    Primary source
    ECOCYC:G6600
    Locus tag
    b1160
    See related
    ASAP:ABE-0003893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1147; elb1; elbA; ycgW
    Summary
    IraM(ElbA) is involved in isoprenoid biosynthesis (Hemmi, 1998). [More information is available at EcoGene: EG13885]. In response to Mg2+ starvation, IraM inhibits proteolysis of the stationary phase sigma factor S by interacting with RssB, which would normally target S for degradation by the ClpXP protease . iraM expression is induced during Mg2+/Ca2+ starvation; regulation is dependent on PhoP . [More information is available at EcoCyc: G6600].
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    Genomic context

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    Sequence:
    NC_000913.3 (1211680..1212003, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Type IV methyl-directed restriction enzyme EcoKMcrA Neighboring gene pseudo Neighboring gene protein YmgK Neighboring gene protein YmgL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IraM remodels the RssB segmented helical linker to stabilize σ(s) against degradation by ClpXP. Brugger C, et al. J Biol Chem, 2024 Feb. PMID 38103640, Free PMC Article
    2. Regulation of acid resistance by connectors of two-component signal transduction systems in Escherichia coli. Eguchi Y, et al. J Bacteriol, 2011 Mar. PMID 21193607, Free PMC Article
    3. Genome-wide identification of transcription start sites, promoters and transcription factor binding sites in E. coli. Mendoza-Vargas A, et al. PLoS One, 2009 Oct 19. PMID 19838305, Free PMC Article
    4. Identification of genes affecting lycopene formation in Escherichia coli transformed with carotenoid biosynthetic genes: candidates for early genes in isoprenoid biosynthesis. Hemmi H, et al. J Biochem, 1998 Jun. PMID 9603997
    5. MgrB affects the acid stress response of Escherichia coli by modulating the expression of iraM. Xu J, et al. FEMS Microbiol Lett, 2019 Jun 1. PMID 31158277

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IraM remodels the RssB segmented helical linker to stabilize sigma[s] against degradation by ClpXP.
      Title: IraM remodels the RssB segmented helical linker to stabilize σ(s) against degradation by ClpXP.
    2. data suggest that MgrB affects the acid resistance of E. coli by modulating the expression of iraM, but not completely through PhoP/Q.
      Title: MgrB affects the acid stress response of Escherichia coli by modulating the expression of iraM.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables anti-sigma factor antagonist activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to magnesium starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to magnesium starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anti-adaptor protein IraM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1211680..1212003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415678.1 anti-adaptor protein IraM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415678.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EN72
      Conserved Domains (1) summary
      PRK09919
      Location:1 → 107
      PRK09919; anti-adapter protein IraM; Provisional
    Nucleotide Protein
    Heading Accession and Version

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