minC Z-ring positioning protein MinC [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Go to the top of the page Help

Official Symbol: minC
Official Full Name: Z-ring positioning protein MinC
Primary source: ECOCYC:EG10596
Locus tag: b1176
See related: ASAP:ABE-0003941
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1164; minB
Summary: MinCD oscillates (migrates) between coating one half of the cell's membrane (minE ring to pole) to coating the other half every 40 secs, and this may help to identify the cell center. [More information is available at EcoGene: EG10596]. MinC acts to ensure correct placement of the septum during cell division by suppressing formation of septa at aberrant loci within the cell. [More information is available at EcoCyc: EG10596].
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Sequence:: NC_000913.3 (1225385..1226080, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Min waves without MinC can pattern FtsA-anchored FtsZ filaments on model membranes.
Title: Min waves without MinC can pattern FtsA-anchored FtsZ filaments on model membranes.
The results suggest that DicB is a pleiotropic regulator of bacterial physiology and cell division and that these effects are mediated by a key molecular interaction with the cell division protein MinC.
Title: Cryptic-Prophage-Encoded Small Protein DicB Protects Escherichia coli from Phage Infection by Inhibiting Inner Membrane Receptor Proteins.
The authors identified amino acids in both the N- and C-domains of MinC that are important for direct interactions with FtsZ and MinD in vitro, as well as mutations that modify the observed in vivo oscillation of green fluorescent protein (GFP)-MinC fusion protein.
Title: MinC N- and C-Domain Interactions Modulate FtsZ Assembly, Division Site Selection, and MinD-Dependent Oscillation in Escherichia coli.
Characterization of C-terminal structure of MinC and its implication in evolution of bacterial cell division has been presented.
Title: Characterization of C-terminal structure of MinC and its implication in evolution of bacterial cell division.
Non-linear Min protein interactions generate harmonics that signal mid-cell division in Escherichia coli.
Title: Non-linear Min protein interactions generate harmonics that signal mid-cell division in Escherichia coli.
A membrane anchored MinC/MinD complex is targeted to the Z ring through the conserved carboxy tail of FtsZ leading to breakage of FtsZ filaments.
Title: MinC/MinD copolymers are not required for Min function.
In the process of E. coli cell division, MinC-MinD copolymers bind to membrane, interact with FtsZ, and are disassembled by MinE.
Title: MinCD cell division proteins form alternating copolymeric cytomotive filaments.
The MinCDE proteins prevent the formation of the Z-ring at poles by oscillating from pole to pole, thereby ensuring that the concentration of the Z-ring inhibitor, MinC, is lowest at the cell center.
Title: MinC, MinD, and MinE drive counter-oscillation of early-cell-division proteins prior to Escherichia coli septum formation.
The binding sites for MinC and MinE overlap and reveals that they are at the MinD dimer interface.
Title: Determination of the structure of the MinD-ATP complex reveals the orientation of MinD on the membrane and the relative location of the binding sites for MinE and MinC.
Taken together, these data indicate that polar Z rings are more susceptible to MinC/MinD than internal Z rings, even when MinE is absent.
Title: Differences in MinC/MinD sensitivity between polar and internal Z rings in Escherichia coli.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell septum assembly	IEA Inferred from Electronic Annotation more info
involved_in division septum assembly	IEA Inferred from Electronic Annotation more info
involved_in division septum site selection	IDA Inferred from Direct Assay more info	PubMed
involved_in division septum site selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell septum assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell pole	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Z-ring positioning protein MinC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

1225385..1226080 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_415694.1 Z-ring positioning protein MinC [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_415694.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A7I6H3C0

Conserved Domains (1) summary

PRK03511
Location:1 → 231

minC; septum site-determining protein MinC