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    insC2 IS2 insertion element repressor InsA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945967, updated on 17-Dec-2024

    Summary

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    Official Symbol
    insC2
    Official Full Name
    IS2 insertion element repressor InsA
    Primary source
    ECOCYC:G6724
    Locus tag
    b1403
    See related
    ASAP:ABE-0004685
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0357; yi21-2
    Summary
    IS2E is a partial IS2 sequence and has insC deleted. [More information is available at EcoGene: EG60028]. InsA is a transcriptional repressor for the insertion element IS2. [More information is available at EcoCyc: G6724].
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    Genomic context

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    Sequence:
    NC_000913.3 (1468784..1469149, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor PaaX Neighboring gene 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase Neighboring gene uncharacterized protein YnbG Neighboring gene pseudo Neighboring gene IS2 insertion element protein InsB Neighboring gene IS30 family transposase Neighboring gene pyridoxal reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of IS2 transposition by the cyclic AMP (cAMP)-cAMP receptor protein complex. Hu ST, et al. J Bacteriol, 1998 May. PMID 9573153, Free PMC Article
    2. Functional domains of the InsA protein of IS2. Lei GS, et al. J Bacteriol, 1997 Oct. PMID 9335268, Free PMC Article
    3. Functional analysis of the 14 kDa protein of insertion sequence 2. Hu ST, et al. J Mol Biol, 1994 Feb 18. PMID 8107136
    4. Transcription initiation sites within an IS2 insertion in a Gal-constitutive mutant of Escherichia coli. Hinton DM, et al. Nucleic Acids Res, 1982 Aug 25. PMID 6291000, Free PMC Article
    5. IS2, a genetic element for turn-off and turn-on of gene activity in E. coli. Saedler H, et al. Mol Gen Genet, 1974. PMID 4610339

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transposase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transposition IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IS2 insertion element repressor InsA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1468784..1469149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415921.2 IS2 insertion element repressor InsA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415921.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0K5STT8, A0A2P9ELD4, A0A2X3BHA0, A0A2Y0AFV9, A0A376IUY9, A0A376J773, A0A376JW60, A0A376ZRC6, A0A377DG20, A0A377HC68, A0A446GLX8, A0A836N848, A0AAP7TKR5, A0AAQ1TAP0, B3Y0T5, F4SUN9
      Conserved Domains (1) summary
      PRK09413
      Location:1 → 121
      PRK09413; IS2 repressor TnpA; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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