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    hicB antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946001, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hicB
    Official Full Name
    antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB
    Primary source
    ECOCYC:G6749
    Locus tag
    b1438
    See related
    ASAP:ABE-0004796
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1432; ydcQ
    Summary
    IS insertions in ydcQ were isolated as suppressors of rpoE lethality; in wt cells, ydcQ mutants downregulate extracytoplasmic stress responses and OM vesicle production is reduced (Button, 2006). [More information is available at EcoGene: EG13760]. The loss of YdcQ downregulates the extracytoplasmic stress response mediated by E and the production of outer membrane vesicles. [More information is available at EcoCyc: G6749].
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    Genomic context

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    Sequence:
    NC_000913.3 (1509508..1509924)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2554 domain-containing protein YncJ Neighboring gene mRNA interferase toxin HicA Neighboring gene fused putative DNA-binding transcriptional regulator/putative aminotransferase YdcR Neighboring gene putative ABC transporter periplasmic binding protein/polyhydroxybutyrate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain. Manav MC, et al. Structure, 2019 Nov 5. PMID 31495532
    2. HicA toxin of Escherichia coli derepresses hicAB transcription to selectively produce HicB antitoxin. Turnbull KJ, et al. Mol Microbiol, 2017 Jun. PMID 28266056
    3. A suppressor of cell death caused by the loss of sigmaE downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli. Button JE, et al. J Bacteriol, 2007 Mar. PMID 17172327, Free PMC Article
    4. HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. Jørgensen MG, et al. J Bacteriol, 2009 Feb. PMID 19060138, Free PMC Article
    5. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Pérez-Rueda E, et al. Comput Biol Chem, 2004 Dec. PMID 15556475

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1509508..1509924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415955.2 antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415955.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A066QJ67, A0A140NAH6, A0A7I6GYM5, A0A7I8ZKN2, A7ZLN1
      Conserved Domains (2) summary
      COG1598
      Location:1 → 73
      HicB; Predicted nuclease of the RNAse H fold, HicB family [Defense mechanisms]
      pfam01381
      Location:91 → 136
      HTH_3; Helix-turn-helix
    Nucleotide Protein
    Heading Accession and Version

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