gdhA glutamate dehydrogenase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: gdhA
Official Full Name: glutamate dehydrogenase
Primary source: ECOCYC:EG10372
Locus tag: b1761
See related: ASAP:ABE-0005865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1759
Summary: Glutamate dehydrogenase catalyzes the amination step in the ATP-dependent glutamate synthase pathway. [More information is available at EcoCyc: EG10372].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

EcGDH deviates from Michaelis-Menten kinetics, exhibiting apparent mild negative co-operativity with both l-glutamate and NADP+.
Title: Apparent negative co-operativity and substrate inhibition in overexpressed glutamate dehydrogenase from Escherichia coli.
N-terminus verified by Edman degradation on complete protein
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glutamate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables glutamate dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables guanosine tetraphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutamate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of glutamate dehydrogenase complex	IPI Inferred from Physical Interaction more info	PubMed

NP_416275.1

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The following sections contain reference sequences that belong to a specific genome build. Explain