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    rlmA 23S rRNA m(1)G745 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946340, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rlmA
    Official Full Name
    23S rRNA m(1)G745 methyltransferase
    Primary source
    ECOCYC:EG12207
    Locus tag
    b1822
    See related
    ASAP:ABE-0006067
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1820; rrmA; yebH
    Summary
    RrmA is the methyltransferase responsible for methylation of 23S rRNA at the N1 position of the G745 nucleotide. [More information is available at EcoCyc: EG12207].
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    Genomic context

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    Sequence:
    NC_000913.3 (1906251..1907060, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene mannose-specific PTS enzyme IID component Neighboring gene DUF986 domain-containing inner membrane protein YobD Neighboring gene Mn(2(+)) exporter Neighboring gene transcription antiterminator and regulator of mRNA stability CspC Neighboring gene DUF2527 domain-containing protein YobF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase. Liu M, et al. RNA, 2004 Nov. PMID 15388872, Free PMC Article
    2. Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria. Liu M, et al. Mol Microbiol, 2002 Apr. PMID 11967079
    3. Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus. Bujnicki JM, et al. J Mol Microbiol Biotechnol, 2002 Jan. PMID 11763974
    4. Partial purification of ribosomal RNA(m1G)- and rRNA(m2G)-methylases from Escherichia coli and demonstration of some proteins affecting their apparent activity. Isaksson LA. Biochim Biophys Acta, 1973 Jun 8. PMID 4580201
    5. Isolation of mutants of Escherichia coli lac king 5-methyluracil in transfer ribonucleic acid or 1-methylguanine in ribosomal RNA. Björk GR, et al. J Mol Biol, 1970 Jul 14. PMID 4921251

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 23S rRNA (guanine(745)-N(1))-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (guanine-N1-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA base methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    23S rRNA m(1)G745 methyltransferase
    NP_416336.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1906251..1907060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416336.1 23S rRNA m(1)G745 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416336.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TZ31, A0A6M9WPN6
      Conserved Domains (1) summary
      PRK11088
      Location:1 → 269
      rrmA; 23S rRNA methyltransferase A; Provisional
    Nucleotide Protein
    Heading Accession and Version

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