cspC transcription antiterminator and regulator of mRNA stability CspC [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: cspC
Official Full Name: transcription antiterminator and regulator of mRNA stability CspC
Primary source: ECOCYC:EG12204
Locus tag: b1823
See related: ASAP:ABE-0006070
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1821; msmB
Summary: HT_Cmplx32_Mem: [More information is available at EcoGene: EG12204]. CspC has transcription antiterminator activity at -independent terminators in vitro and in vivo . [More information is available at EcoCyc: EG12204].
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Genomic context

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Sequence:: NC_000913.3 (1907226..1907435, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of CspC in response to diverse environmental stressors in Escherichia coli.
Title: Involvement of CspC in response to diverse environmental stressors in Escherichia coli.
A Revised Understanding of Clostridioides difficile Spore Germination.
Title: A Revised Understanding of Clostridioides difficile Spore Germination.
Evidence is provided for an interaction between GroESL and CspC that results in enhanced, temperature-dependent proteolysis of the latter.
Title: Novel interaction between the major bacterial heat shock chaperone (GroESL) and an RNA chaperone (CspC).
study shows that CspC interacts with Hfq via mRNA molecules; also show that CspC acts on the 5' UTR of the rpoS transcript, but its activity on rpoS is independent of Hfq; show that CspC suppresses the phenotypes of an hfq deletion
Title: CspC regulates rpoS transcript levels and complements hfq deletions.
N-terminus verified by Edman degradation on mature peptide
Title: Small genes/gene-products in Escherichia coli K-12.
Global transcript profiles of cells lacking cspE and cspC as well as cells individually overexpressing these proteins or a CspE mutant that is unable to melt nucleic acids and is defective in cold acclimation are reported.
Title: Analysis of Escherichia coli global gene expression profiles in response to overexpression and deletion of CspC and CspE.
results ascribe a novel role in cellular growth at 37 degrees C for CspC, a member of the cold shock domain-containing protein family.
Title: Loss of expression of cspC, a cold shock family gene, confers a gain of fitness in Escherichia coli K-12 strains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription antitermination factor activity, RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of termination of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription antitermination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: transcription antiterminator and regulator of mRNA stability CspC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

1907226..1907435 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_416337.1 transcription antiterminator and regulator of mRNA stability CspC [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_416337.1

Status: PROVISIONAL

UniProtKB/TrEMBL

Q1PG46

Conserved Domains (1) summary

PRK10943
Location:1 → 69

PRK10943; cold shock-like protein CspC; Provisional