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    fcl GDP-L-fucose synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946563, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fcl
    Official Full Name
    GDP-L-fucose synthase
    Primary source
    ECOCYC:EG11788
    Locus tag
    b2052
    See related
    ASAP:ABE-0006801
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2046; wcaG; yefB
    Summary
    GDP-fucose synthase is a bifunctional enzyme that catalyzes the two-step synthesis of GDP-fucose from GDP-4-dehydro-6-deoxy-D-mannose via a GDP-4-dehydro-6-L-deoxygalactose intermediate . [More information is available at EcoCyc: EG11788].
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    Genomic context

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    Sequence:
    NC_000913.3 (2126225..2127190, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene mannose-1-phosphate guanylyltransferase Neighboring gene colanic acid biosynthesis fucosyltransferase WcaI Neighboring gene GDP-mannose mannosyl hydrolase Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene colanic acid biosynthesis acetyltransferase WcaF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary crystallographic investigations of recombinant GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from E. coli. Tonetti M, et al. Acta Crystallogr D Biol Crystallogr, 1998 Jul 1. PMID 9761875
    2. GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from Escherichia coli, a key enzyme in the biosynthesis of GDP-L-fucose, displays the structural characteristics of the RED protein homology superfamily. Rizzi M, et al. Structure, 1998 Nov 15. PMID 9817848
    3. Studies on the biosynthesis of guanosine diphosphate L-fucose. GINSBURG V. J Biol Chem, 1961 Sep. PMID 13705522
    4. GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. Somers WS, et al. Structure, 1998 Dec 15. PMID 9862812
    5. The metabolism of 6-deoxyhexoses in bacterial and animal cells. Tonetti M, et al. Biochimie, 1998 Nov. PMID 9893952

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GDP-L-fucose synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-L-fucose synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-L-fucose synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in colanic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-sugar biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GDP-L-fucose synthase
    NP_416556.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2126225..2127190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416556.1 GDP-L-fucose synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416556.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BPM6
      Conserved Domains (1) summary
      cd05239
      Location:5 → 313
      GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version

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