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    menE o-succinylbenzoate--CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946741, updated on 3-Dec-2024

    Summary

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    Official Symbol
    menE
    Official Full Name
    o-succinylbenzoate--CoA ligase
    Primary source
    ECOCYC:EG12437
    Locus tag
    b2260
    See related
    ASAP:ABE-0007471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2254
    Summary
    O-succinylbenzoate-CoA ligase catalyzes the formation of an intermediate in menaquinone biosynthesis, o-succinylbenzoyl-CoA . [More information is available at EcoCyc: EG12437].
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    Genomic context

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    Sequence:
    NC_000913.3 (2373648..2375003, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate synthase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase Neighboring gene 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Neighboring gene 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. Matarlo JS, et al. Biochemistry, 2015 Oct 27. PMID 26394156, Free PMC Article
    2. Vitamin K2 (menaquinone) biosynthesis in Escherichia coli: evidence for the presence of an essential histidine residue in o-succinylbenzoyl coenzyme A synthetase. Bhattacharyya DK, et al. J Bacteriol, 1997 Oct. PMID 9324253, Free PMC Article
    3. Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and properties of o-succinylbenzoyl-coenzyme A synthetase from Escherichia coli. Kwon O, et al. J Bacteriol, 1996 Dec. PMID 8955296, Free PMC Article
    4. Role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12. Ma J, et al. Environ Microbiol, 2009 Jan. PMID 18811645
    5. Characterization of Escherichia coli men mutants defective in conversion of o-succinylbenzoate to 1,4-dihydroxy-2-naphthoate. Shaw DJ, et al. J Bacteriol, 1982 Dec. PMID 6754698, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. X-ray crystallography and site-directed mutagenesis confirm the importance of a conserved arginine for binding the o-succinylbenzoyl carboxylate.
      Title: Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.
    2. The results showed that E. coli K12 carrying a deletion of either the menD, menC or menE gene was unable to reduce selenate.
      Title: Role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-sulfur bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables o-succinylbenzoate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables o-succinylbenzoate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables o-succinylbenzoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in menaquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in menaquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within menaquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    o-succinylbenzoate--CoA ligase
    NP_416763.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2373648..2375003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416763.1 o-succinylbenzoate--CoA ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416763.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WVJ5
      Conserved Domains (1) summary
      PRK09029
      Location:1 → 451
      PRK09029; O-succinylbenzoic acid--CoA ligase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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