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    gabP 4-aminobutanoate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948049, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gabP
    Official Full Name
    4-aminobutanoate:H(+) symporter
    Primary source
    ECOCYC:EG11330
    Locus tag
    b2663
    See related
    ASAP:ABE-0008763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2657
    Summary
    GabP is a 4-aminobutyrate (GABA) transporter that is a member of the Amino Acid Polyamine Organocation (APC) Superfamily of transporters . [More information is available at EcoCyc: EG11330].
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    Genomic context

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    Sequence:
    NC_000913.3 (2794253..2795653)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinate-semialdehyde dehydrogenase (NADP(+)) GabD Neighboring gene 4-aminobutyrate aminotransferase GabT Neighboring gene DNA-binding transcriptional repressor GlaR Neighboring gene K(+) binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate specificity of the Escherichia coli 4-aminobutyrate carrier encoded by gabP. Uptake and counterflow of structurally diverse molecules. Brechtel CE, et al. J Biol Chem, 1996 Jan 12. PMID 8557687
    2. Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli. Zhang W, et al. J Biol Chem, 2005 Jul 15. PMID 15890647
    3. Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP. King SC, et al. J Bacteriol, 1995 Sep. PMID 7665533, Free PMC Article
    4. Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP. King SC, et al. Biochem J, 2003 Dec 15. PMID 12956624, Free PMC Article
    5. Induction of substrate specificity shifts by placement of alanine insertions within the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP. King SC, et al. Biochem J, 2003 Dec 15. PMID 12956623, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GabP of Escherichia coli is affected both topologically and kinetically by membrane lipids
      Title: Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables gamma-aminobutyric acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gamma-aminobutyric acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to nitrogen starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to carbon starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-aminobutanoate:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2794253..2795653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417149.1 4-aminobutanoate:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417149.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M3V8
      Conserved Domains (1) summary
      PRK10197
      Location:21 → 466
      PRK10197; GABA permease
    Nucleotide Protein
    Heading Accession and Version

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