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    fkpA peptidyl-prolyl cis-trans isomerase FkpA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947850, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fkpA
    Official Full Name
    peptidyl-prolyl cis-trans isomerase FkpA
    Primary source
    ECOCYC:G7716
    Locus tag
    b3347
    See related
    ASAP:ABE-0010938
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3334; yzzS
    Summary
    An fkpA, surA, ppiB, ppiD quadruple mutant is viable. [More information is available at EcoGene: EG12900]. FkpA is a heat shock peptidyl-prolyl isomerase (PPIase) which also has chaperone function. [More information is available at EcoCyc: G7716].
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    Genomic context

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    Sequence:
    NC_000913.3 (3476607..3477419, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sulfurtransferase complex subunit TusC Neighboring gene sulfurtransferase complex subunit TusD Neighboring gene DNA-binding transcriptional regulator YheO Neighboring gene protein SlyX Neighboring gene FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Periplasmic chaperone FkpA is essential for imported colicin M toxicity. Hullmann J, et al. Mol Microbiol, 2008 Aug. PMID 18554332, Free PMC Article
    2. The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. II. Isomerase-independent chaperone activity in vitro. Ramm K, et al. J Biol Chem, 2000 Jun 2. PMID 10748201
    3. Chaperone function of FkpA, a heat shock prolyl isomerase, in the periplasm of Escherichia coli. Arié JP, et al. Mol Microbiol, 2001 Jan. PMID 11123702
    4. Production of soluble and functional engineered antibodies in Escherichia coli improved by FkpA. Zhang Z, et al. Biotechniques, 2003 Nov. PMID 14628677
    5. Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. Horne SM, et al. Arch Microbiol, 1995 May. PMID 7540828

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phage HK97 genome injection requires the activities of the inner membrane glucose transporter protein, PtsG, and the periplasmic chaperone, FkpA and requirements for PtsG and FkpA are determined by the sequence of the phage tape measure protein.
      Title: The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97.
    2. FkpA specifically assists in folding colicin M into an active toxin in the periplasm and PPIase is essential for colicin M activity.
      Title: Periplasmic chaperone FkpA is essential for imported colicin M toxicity.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FkpA
    NP_417806.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3476607..3477419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417806.1 peptidyl-prolyl cis-trans isomerase FkpA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417806.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GC96, A0A377ACT4
      Conserved Domains (1) summary
      PRK10902
      Location:1 → 259
      PRK10902; FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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