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    bcsA cellulose synthase catalytic subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948053, updated on 3-Dec-2024

    Summary

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    Official Symbol
    bcsA
    Official Full Name
    cellulose synthase catalytic subunit
    Primary source
    ECOCYC:EG12260
    Locus tag
    b3533
    See related
    ASAP:ABE-0011547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3518; yhjO; yhjP
    Summary
    BcsA has a C-terminal PilZ domain, which has been implicated in cyclic-di-GMP binding to YcgR. [More information is available at EcoGene: EG12260]. BcsA, BcsB, BcsZ and BcsC are involved in biosynthesis of cellulose, a characteristic of the rdar morphotype . [More information is available at EcoCyc: EG12260].
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    Genomic context

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    Sequence:
    NC_000913.3 (3692618..3695236, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cellulose synthase outer membrane channel Neighboring gene endo-1,4-D-glucanase Neighboring gene cellulose synthase periplasmic subunit Neighboring gene pseudo Neighboring gene PF10945 family protein YhjR Neighboring gene c-di-GMP-binding protein BcsE Neighboring gene putative cellulose biosynthesis protein BcsF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Architecture of the Cellulose Synthase Outer Membrane Channel and Its Association with the Periplasmic TPR Domain. Acheson JF, et al. Structure, 2019 Dec 3. PMID 31604608, Free PMC Article
    2. Cellulose as an architectural element in spatially structured Escherichia coli biofilms. Serra DO, et al. J Bacteriol, 2013 Dec. PMID 24097954, Free PMC Article
    3. Cellulose modulates biofilm formation by counteracting curli-mediated colonization of solid surfaces in Escherichia coli. Gualdi L, et al. Microbiology (Reading), 2008 Jul. PMID 18599830
    4. Tight modulation of Escherichia coli bacterial biofilm formation through controlled expression of adhesion factors. Da Re S, et al. Appl Environ Microbiol, 2007 May. PMID 17384304, Free PMC Article
    5. Crl activates transcription initiation of RpoS-regulated genes involved in the multicellular behavior of Salmonella enterica serovar Typhimurium. Robbe-Saule V, et al. J Bacteriol, 2006 Jun. PMID 16707690, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cellulose synthase (UDP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cellulose synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic-di-GMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-alpha-D-glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bacterial cellulose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellulose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cellulose synthase catalytic subunit
    NP_417990.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3692618..3695236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417990.4 cellulose synthase catalytic subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417990.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A776LWK4
      Conserved Domains (1) summary
      PRK11498
      Location:15 → 865
      bcsA; cellulose synthase catalytic subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version

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