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    nnr NAD(P)HX epimerase/NAD(P)HX dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948685, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nnr
    Official Full Name
    NAD(P)HX epimerase/NAD(P)HX dehydratase
    Primary source
    ECOCYC:EG11758
    Locus tag
    b4167
    See related
    ASAP:ABE-0013644
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4163; yjeF
    Summary
    Insertions in yjeF indicate this gene is likely to be non-essential. [More information is available at EcoGene: EG11758].
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    Genomic context

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    Sequence:
    NC_000913.3 (4394066..4395613)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene uncharacterized protein YjeV Neighboring gene epoxyqueuosine reductase Neighboring gene N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit Neighboring gene N-acetylmuramoyl-L-alanine amidase B Neighboring gene DNA mismatch repair protein MutL Neighboring gene tRNA dimethylallyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. Marbaix AY, et al. J Biol Chem, 2011 Dec 2. PMID 21994945, Free PMC Article
    2. The mutL repair gene of Escherichia coli K-12 forms a superoperon with a gene encoding a new cell-wall amidase. Tsui HC, et al. Mol Microbiol, 1994 Jan. PMID 7511774
    3. Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K-12 from clustered Esigma32-specific promoters during heat shock. Tsui HC, et al. J Bacteriol, 1996 Oct. PMID 8824618, Free PMC Article
    4. Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K-12. Tsui HC, et al. Mol Microbiol, 1994 Jul. PMID 7984093
    5. Transcriptional patterns of the mutL-miaA superoperon of Escherichia coli K-12 suggest a model for posttranscriptional regulation. Tsui HC, et al. Biochimie, 1994. PMID 7748952

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP-dependent NAD(P)H-hydrate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-dependent NAD(P)H-hydrate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ADP-dependent NAD(P)H-hydrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)HX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)HX epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD(P)HX epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metabolite repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within metabolite repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nicotinamide nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)HX epimerase/NAD(P)HX dehydratase
    NP_418588.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4394066..4395613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418588.1 NAD(P)HX epimerase/NAD(P)HX dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418588.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A061K9P0, A0A836ZC61, A0A8E0FI96
      Conserved Domains (1) summary
      PRK10565
      Location:1 → 508
      PRK10565; putative carbohydrate kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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