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    lptG lipopolysaccharide transport system protein LptG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945324, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lptG
    Official Full Name
    lipopolysaccharide transport system protein LptG
    Primary source
    ECOCYC:G7889
    Locus tag
    b4262
    See related
    ASAP:ABE-0013960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4255; yjgQ
    Summary
    YjgQ is an inner membrane protein with six predicted transmembrane domains. [More information is available at EcoCyc: G7889].
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    Genomic context

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    Sequence:
    NC_000913.3 (4487318..4488400)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YtgB Neighboring gene protein YtgA Neighboring gene lipopolysaccharide transport system protein LptF Neighboring gene DUF853 domain-containing protein YjgR Neighboring gene DNA-binding transcriptional dual regulator IdnR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane. Bertani BR, et al. Mol Microbiol, 2018 Aug. PMID 29995974, Free PMC Article
    2. Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function. Simpson BW, et al. mBio, 2016 Oct 18. PMID 27795402, Free PMC Article
    3. Structural basis of lipopolysaccharide extraction by the LptB(2)FGC complex. Li Y, et al. Nature, 2019 Mar. PMID 30894744, Free PMC Article
    4. Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides. Narita S, et al. FEBS Lett, 2009 Jul 7. PMID 19500581
    5. Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Sherman DJ, et al. Science, 2018 Feb 16. PMID 29449493, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors define residue K34 in LptG as a site within the structural cavity of the Escherichia coli LptB2 FG transporter that interacts electrostatically with phosphates on unmodified lipopolysaccharides.
      Title: A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane.
    2. Taken together, these data identify a specific binding site in LptB for the coupling helices of LptFG that is responsible for coupling of ATP hydrolysis by LptB with LptFG function to achieve lipopolysaccharide extraction.
      Title: Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function.
    3. both LptF and LptG formed a complex with LptB.
      Title: Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides.
    4. YjgP and YjgQ are required for the transport of LPS to the cell surface.
      Title: Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Gram-negative-bacterium-type cell outer membrane assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in lipopolysaccharide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipopolysaccharide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipopolysaccharide transport system protein LptG
    NP_418683.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4487318..4488400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418683.4 lipopolysaccharide transport system protein LptG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418683.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3JRU8, C3SEX2
      Conserved Domains (1) summary
      PRK15071
      Location:4 → 359
      PRK15071; lipopolysaccharide ABC transporter permease; Provisional
    Nucleotide Protein
    Heading Accession and Version

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