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    prpC 2-methylcitrate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947528, updated on 3-Dec-2024

    Summary

    Official Symbol
    prpC
    Official Full Name
    2-methylcitrate synthase
    Primary source
    ECOCYC:G6198
    Locus tag
    b0333
    See related
    ASAP:ABE-0001148
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0330; yahS; yzzD
    Summary
    Repressed during biofilm formation. [More information is available at EcoGene: EG11756]. Regulation has been described . [More information is available at EcoCyc: G6198].
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    Genomic context

    Sequence:
    NC_000913.3 (350012..351181)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator PrpR Neighboring gene 2-methylisocitrate lyase Neighboring gene 2-methylcitrate dehydratase Neighboring gene propionyl-CoA synthetase

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-methylcitrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 2-methylcitrate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 2-methylcitrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
     
    enables citrate (Si)-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables citrate (Si)-synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables citrate (Si)-synthase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables citrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in propionate metabolic process, methylcitrate cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within propionate metabolic process, methylcitrate cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in propionate metabolic process, methylcitrate cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    2-methylcitrate synthase
    NP_414867.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      350012..351181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414867.1 2-methylcitrate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414867.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X4G5
      Conserved Domains (1) summary
      PRK12351
      Location:15388
      PRK12351; methylcitrate synthase; Provisional