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    mhpE 4-hydroxy-2-oxovalerate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945012, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mhpE
    Official Full Name
    4-hydroxy-2-oxovalerate aldolase
    Primary source
    ECOCYC:G6205
    Locus tag
    b0352
    See related
    ASAP:ABE-0001209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0349
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    Genomic context

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    Sequence:
    NC_000913.3 (373868..374881)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase Neighboring gene 2-hydroxypentadienoate hydratase Neighboring gene acetaldehyde dehydrogenase (acetylating) MhpF Neighboring gene 3-hydroxyphenylpropionate/3-hydroxycinnamate:H(+) symporter Neighboring gene DUF2058 domain-containing protein YaiL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stereospecificity in meta-fission catabolic pathways. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345511, Free PMC Article
    2. Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli. Bugg TD. Biochim Biophys Acta, 1993 Oct 6. PMID 8399388
    3. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
    4. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
    5. Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli. Pollard JR, et al. Appl Environ Microbiol, 1998 Oct. PMID 9758851, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression of mhpE occurs only when MhpF is available for the formation of a complex
      Title: Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-isopropylmalate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-hydroxy-2-oxovalerate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-hydroxy-2-oxovalerate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3-phenylpropionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-hydroxy-2-oxovalerate aldolase
    NP_414886.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      373868..374881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414886.1 4-hydroxy-2-oxovalerate aldolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414886.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MIS2, A0A376DCC7, A0A5B9AM61
      Conserved Domains (1) summary
      PRK08195
      Location:3 → 333
      PRK08195; 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated
    Nucleotide Protein
    Heading Accession and Version

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