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    dacC D-alanyl-D-alanine carboxypeptidase DacC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945455, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dacC
    Official Full Name
    D-alanyl-D-alanine carboxypeptidase DacC
    Primary source
    ECOCYC:EG10203
    Locus tag
    b0839
    See related
    ASAP:ABE-0002860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0829
    Summary
    PBP6 is a penicillin-binding protein that is required for proper cell morphology and provides some resistance to penicillin . [More information is available at EcoCyc: EG10203].
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    Genomic context

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    Sequence:
    NC_000913.3 (880727..881929)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of biofilm formation Neighboring gene aldose sugar dehydrogenase YliI Neighboring gene glutathione S-transferase GstB Neighboring gene DNA-binding transcriptional repressor DeoR Neighboring gene undecaprenyl pyrophosphate phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of penicillin-binding protein 6 from Escherichia coli. Chen Y, et al. J Am Chem Soc, 2009 Oct 14. PMID 19807181, Free PMC Article
    2. Possible role of Escherichia coli penicillin-binding protein 6 in stabilization of stationary-phase peptidoglycan. van der Linden MP, et al. J Bacteriol, 1992 Dec. PMID 1447130, Free PMC Article
    3. Deletion of the penicillin-binding protein 6 gene of Escherichia coli. Broome-Smith JK, et al. J Bacteriol, 1982 Nov. PMID 6215397, Free PMC Article
    4. Identification of gene products programmed by restriction endonuclease DNA fragments using an E. coli in vitro system. Pratt JM, et al. Nucleic Acids Res, 1981 Sep 25. PMID 6272207, Free PMC Article
    5. Synthesis of penicillin-binding protein 6 by stationary-phase Escherichia coli. Buchanan CE, et al. J Bacteriol, 1982 Jul. PMID 7045084, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present report shows that BolA is a transcriptional regulator of the dacA and dacC genes, thus regulating both DD-carboxypeptidases PBP5 and PBP6 and thereby demonstrating the versatility of BolA as a cellular regulator.
      Title: BolA affects cell growth, and binds to the promoters of penicillin-binding proteins 5 and 6 and regulates their expression.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Amino acid sequence homologies between Escherichia coli penicillin-binding protein 5 and class A beta-lactamases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables penicillin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type D-Ala-D-Ala carboxypeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-alanyl-D-alanine carboxypeptidase DacC
    NP_415360.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      880727..881929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415360.1 D-alanyl-D-alanine carboxypeptidase DacC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415360.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      H9TVI7
      Conserved Domains (1) summary
      PRK10001
      Location:1 → 400
      PRK10001; serine-type D-Ala-D-Ala carboxypeptidase
    Nucleotide Protein
    Heading Accession and Version

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