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    tsaB N(6)-L-threonylcarbamoyladenine synthase, TsaB subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946304, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tsaB
    Official Full Name
    N(6)-L-threonylcarbamoyladenine synthase, TsaB subunit
    Primary source
    ECOCYC:G6991
    Locus tag
    b1807
    See related
    ASAP:ABE-0006013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1805; yeaZ
    Summary
    AFMB Structural Genomics target Number 123 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13512]. The preliminary analysis of a crystal structure of the predicted protease YeaZ has been published . [More information is available at EcoCyc: G6991].
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    Genomic context

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    Sequence:
    NC_000913.3 (1890572..1891267, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene long-chain-fatty-acid--CoA ligase Neighboring gene Slp family lipoprotein YeaY Neighboring gene putative ATP-dependent 5' to 3' DNA helicase Neighboring gene RutC family protein YoaB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary crystallographic analysis of the Escherichia coli YeaZ protein using the anomalous signal of a gadolinium derivative. Jeudy S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Sep 1. PMID 16511176, Free PMC Article
    2. Resuscitation of the viable but non-culturable state of Salmonella enterica serovar Oranienburg by recombinant resuscitation-promoting factor derived from Salmonella Typhimurium strain LT2. Panutdaporn N, et al. Int J Food Microbiol, 2006 Feb 15. PMID 16213054
    3. Grasping at shadows: revealing the elusive nature of essential genes. Msadek T. J Bacteriol, 2009 Aug. PMID 19465656, Free PMC Article
    4. Conserved network of proteins essential for bacterial viability. Handford JI, et al. J Bacteriol, 2009 Aug. PMID 19376873, Free PMC Article
    5. Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance. Oberto J, et al. Nucleic Acids Res, 2009 Sep. PMID 19578062, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in bacteria four proteins (YgjD, YrdC, YjeE, and YeaZ) are both necessary and sufficient for t(6)A biosynthesis in vitro
      Title: Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside.
    2. Deliberate repression of the expression of yeaZ results in cells with highly condensed nucleoids, showing that this gene is essential for the viability of E. coli.
      Title: Conserved network of proteins essential for bacterial viability.
    3. preliminary X ray structure
      Title: Preliminary crystallographic analysis of the Escherichia coli YeaZ protein using the anomalous signal of a gadolinium derivative.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of translational fidelity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA threonylcarbamoyladenosine modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N(6)-L-threonylcarbamoyladenine synthase, TsaB subunit
    NP_416321.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1890572..1891267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416321.1 N(6)-L-threonylcarbamoyladenine synthase, TsaB subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416321.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6Q0F4
      Conserved Domains (1) summary
      COG1214
      Location:1 → 226
      TsaB; tRNA A37 threonylcarbamoyladenosine modification protein TsaB [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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