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    menH 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946736, updated on 3-Dec-2024

    Summary

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    Official Symbol
    menH
    Official Full Name
    2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
    Primary source
    ECOCYC:EG12438
    Locus tag
    b2263
    See related
    ASAP:ABE-0007478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2257; yfbB
    Summary
    MenH catalyzes the third step in the menaquinone biosynthesis pathway, a proton abstraction reaction that results in 2,5-elimination of pyruvate from |FRAME: [More information is available at EcoCyc: EG12438].
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    Genomic context

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    Sequence:
    NC_000913.3 (2376834..2377592, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene o-succinylbenzoate synthase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase Neighboring gene 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase Neighboring gene isochorismate synthase MenF Neighboring gene tail-anchored inner membrane protein ElaB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad. Sun Y, et al. J Biol Chem, 2014 May 30. PMID 24737327, Free PMC Article
    2. Crystal structures of E. coli native MenH and two active site mutants. Johnston JM, et al. PLoS One, 2013. PMID 23637813, Free PMC Article
    3. Catalytic mechanism of SHCHC synthase in the menaquinone biosynthesis of Escherichia coli: identification and mutational analysis of the active site residues. Jiang M, et al. Biochemistry, 2009 Jul 28. PMID 19545176
    4. Menaquinone (vitamin K2) biosynthesis: nucleotide sequence and expression of the menB gene from Escherichia coli. Sharma V, et al. J Bacteriol, 1992 Aug. PMID 1629162, Free PMC Article
    5. Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli. Sharma V, et al. Gene, 1996 Feb 2. PMID 8626063

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within menaquinone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in menaquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
    NP_416766.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2376834..2377592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416766.1 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416766.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JR65
      Conserved Domains (1) summary
      PRK11126
      Location:13 → 252
      PRK11126; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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