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    dusB tRNA-dihydrouridine synthase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947707, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dusB
    Official Full Name
    tRNA-dihydrouridine synthase B
    Primary source
    ECOCYC:EG11311
    Locus tag
    b3260
    See related
    ASAP:ABE-0010700
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3247; yhdG
    Summary
    DusB and DusC together account for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusA accounts for the other half . [More information is available at EcoCyc: EG11311].
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    Genomic context

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    Sequence:
    NC_000913.3 (3410280..3411245)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF997 domain-containing protein YhdT Neighboring gene pantothenate:Na(+) symporter Neighboring gene ribosomal protein L11 methyltransferase Neighboring gene DNA-binding transcriptional dual regulator Fis Neighboring gene DNA adenine methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario. Bou-Nader C, et al. Nucleic Acids Res, 2018 Feb 16. PMID 29294097, Free PMC Article
    2. The E.coli fis promoter is subject to stringent control and autoregulation. Ninnemann O, et al. EMBO J, 1992 Mar. PMID 1547773, Free PMC Article
    3. Escherichia coli host factor for site-specific DNA inversion: cloning and characterization of the fis gene. Koch C, et al. Proc Natl Acad Sci U S A, 1988 Jun. PMID 2837762, Free PMC Article
    4. Isolation of the gene encoding the Hin recombinational enhancer binding protein. Johnson RC, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 2835774, Free PMC Article
    5. Identification of the tRNA-dihydrouridine synthase family. Bishop AC, et al. J Biol Chem, 2002 Jul 12. PMID 11983710

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The complete substrate specificities of the three Escherichia coli Dus tRNA-dihydrouridine synthases have been described, and the crystal structure of DusB has been solved.
      Title: Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA dihydrouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-dihydrouridine synthase B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3410280..3411245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417726.1 tRNA-dihydrouridine synthase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417726.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ANH0
      Conserved Domains (1) summary
      PRK10415
      Location:1 → 321
      PRK10415; tRNA-dihydrouridine synthase B; Provisional
    Nucleotide Protein
    Heading Accession and Version

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