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    CCL15-CCL14 CCL15-CCL14 readthrough (NMD candidate) [ Homo sapiens (human) ]

    Gene ID: 348249, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CCL15-CCL14provided by HGNC
    Official Full Name
    CCL15-CCL14 readthrough (NMD candidate)provided by HGNC
    Primary source
    HGNC:HGNC:44436
    See related
    AllianceGenome:HGNC:44436
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIP5; NCC3; CCL15; HCC-2; LKN-1; MIP-5; NCC-3; Mrp-2b; SCYA15
    Summary
    A cluster of CC chemokine genes exists on chromosome 17q11.2. The CC chemokines are secreted proteins characterized by two adjacent cysteines. The genes chemokine (C-C motif) ligand 14 and chemokine (C-C motif) ligand 15 are adjacent loci and express read-through transcripts spanning both loci. The read-through transcripts were originally interpreted as bicistronic transcripts, but they are represented as non-coding because they are candidates for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Dec 2009]
    Expression
    Broad expression in spleen (RPKM 86.6), fat (RPKM 50.5) and 17 other tissues See more
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    Genomic context

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    See CCL15-CCL14 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35983656..36002038, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36931560..36949941, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34310692..34329084, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene lysozyme like 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:34288003-34288221 Neighboring gene Sharpr-MPRA regulatory region 10414 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene C-C motif chemokine ligand 14 Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:34350127-34350628 Neighboring gene C-C motif chemokine ligand 23 Neighboring gene uncharacterized LOC105371746

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15. Forssmann U, et al. J Leukoc Biol, 2001 Sep. PMID 11527984
    2. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Pardigol A, et al. Proc Natl Acad Sci U S A, 1998 May 26. PMID 9600961, Free PMC Article
    3. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. Nomiyama H, et al. J Interferon Cytokine Res, 1999 Mar. PMID 10213461
    4. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Naruse K, et al. Genomics, 1996 Jun 1. PMID 8661057
    5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Other Names

    • C-C motif chemokine 15
    • CCL15-CCL14 readthrough (non-protein coding)
    • Chemokine CC-2
    • Leukotactin-1
    • MIP-1 delta
    • Macrophage inflammatory protein 5
    • Small-inducible cytokine A15

    Clone Names

    • MGC176618

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027921.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in NM_032965, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC244100, Z70293

    2. NR_027922.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in NM_032965, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC244100, Z70292

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35983656..36002038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      218220..236612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36931560..36949941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_003025.1: Suppressed sequence

      Description
      NG_003025.1: This RefSeq was permanently suppressed because the two loci are no longer considered to be expressed from bicistronic transcripts, and NG_003025.1 is out of scope.
    Nucleotide Protein
    Heading Accession and Version

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