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    hofM DNA utilization protein HofM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947908, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hofM
    Official Full Name
    DNA utilization protein HofM
    Primary source
    ECOCYC:G7739
    Locus tag
    b3395
    See related
    ASAP:ABE-0011079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3382; yrfD
    Summary
    hofM (yrfD)has been demonstrated to have a CRP-S promoter co-regulated by both Crp and Sxy (Cameron, 2006). [More information is available at EcoGene: EG12925]. The yrfD gene product is required for utilization of DNA as the sole source of carbon and energy; yrfD is homologous to genes involved in natural competence and genetic transformation in other bacteria . [More information is available at EcoCyc: G7739].
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    Genomic context

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    Sequence:
    NC_000913.3 (3521972..3522751, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA utilization protein HofQ Neighboring gene DNA utilization protein HofP Neighboring gene DNA utilization protein HofO Neighboring gene DNA utilization protein HofN Neighboring gene peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA Neighboring gene ADP-sugar diphosphatase NudE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PpdD type IV pilin of Escherichia coli K-12 can Be assembled into pili in Pseudomonas aeruginosa. Sauvonnet N, et al. J Bacteriol, 2000 Feb. PMID 10633126, Free PMC Article
    2. Non-canonical CRP sites control competence regulons in Escherichia coli and many other gamma-proteobacteria. Cameron AD, et al. Nucleic Acids Res, 2006. PMID 17068078, Free PMC Article
    3. DNA as a nutrient: novel role for bacterial competence gene homologs. Finkel SE, et al. J Bacteriol, 2001 Nov. PMID 11591672, Free PMC Article
    4. Escherichia coli competence gene homologs are essential for competitive fitness and the use of DNA as a nutrient. Palchevskiy V, et al. J Bacteriol, 2006 Jun. PMID 16707682, Free PMC Article
    5. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within carbon utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA utilization protein HofM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3521972..3522751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417854.4 DNA utilization protein HofM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417854.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3NQN4
      Conserved Domains (1) summary
      COG4972
      Location:15 → 174
      PilM; Tfp pilus assembly protein, ATPase PilM [Cell motility, Extracellular structures]
    Nucleotide Protein
    Heading Accession and Version

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