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    mltD membrane-bound lytic murein transglycosylase D [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945694, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mltD
    Official Full Name
    membrane-bound lytic murein transglycosylase D
    Primary source
    ECOCYC:EG10246
    Locus tag
    b0211
    See related
    ASAP:ABE-0000704
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dniR; ECK0211; yafG
    Summary
    MltD has been shown to be a murein hydrolase using zymography, to cause lysis or osmotically-stabilized spheroplasts when overproduced, and to be inhibited by bulgecin (Dijkstra A.J., Rudd, K.E., and Keck, W., A new member of the transglycosylase family of Escherichia coli displays a Gram-positive hydrolase motif, in "The soluble lytic transglycolsylase family of Escherichia coli", A.J. [More information is available at EcoGene: EG10246]. MltD is a membrane-bound lytic murein transglycosylase. [More information is available at EcoCyc: EG10246].
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    Genomic context

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    Sequence:
    NC_000913.3 (232597..233955, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene endonuclease/exonuclease/phosphatase domain-containing protein YafD Neighboring gene putative S-adenosylmethionine-dependent methyltransferase Neighboring gene hydroxyacylglutathione hydrolase GloB Neighboring gene protein YkfO Neighboring gene putative S-adenosyl-L-methionine-dependent methyltransferase Neighboring gene ribonuclease HI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Folding of a LysM domain: entropy-enthalpy compensation in the transition state of an ideal two-state folder. Nickson AA, et al. J Mol Biol, 2008 Jul 11. PMID 18538343, Free PMC Article
    2. Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli. Kaul M, et al. PLoS Genet, 2024 Feb. PMID 38422114, Free PMC Article
    3. Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Pellegrini M, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200254, Free PMC Article
    4. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Lee M, et al. J Am Chem Soc, 2013 Mar 6. PMID 23421439, Free PMC Article
    5. Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli. Korsak D, et al. Antimicrob Agents Chemother, 2005 Apr. PMID 15793119, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic endotransglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lytic endotransglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic transglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic transglycosylase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane-bound lytic murein transglycosylase D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      232597..233955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414747.1 membrane-bound lytic murein transglycosylase D [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414747.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A9P2ICX7
      Conserved Domains (1) summary
      PRK10783
      Location:1 → 452
      mltD; membrane-bound lytic murein transglycosylase D; Provisional
    Nucleotide Protein
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