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    fadE acyl-CoA dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949007, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fadE
    Official Full Name
    acyl-CoA dehydrogenase
    Primary source
    ECOCYC:G6105
    Locus tag
    b0221
    See related
    ASAP:ABE-0000743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0222; yafH
    Summary
    FadR regulon. [More information is available at EcoGene: EG13145]. The previously uncharacterized yafH open reading frame has been shown to encode the FadE acyl-CoA dehydrogenase enzyme . [More information is available at EcoCyc: G6105].
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    Genomic context

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    Sequence:
    NC_000913.3 (240859..243303, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-oxoglutaramate amidase Neighboring gene periplasmic chaperone, inhibitor of vertebrate C-type lysozyme Neighboring gene D-sedoheptulose 7-phosphate isomerase Neighboring gene putative glutamine amidotransferase YafJ Neighboring gene peptidoglycan meso-diaminopimelic acid protein amidase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Study on regulation of long-chain fatty acid metabolism with the use of computer analysis of complete bacterial genomes]. Sadovskaia NS, et al. Mol Biol (Mosk), 2001 Nov-Dec. PMID 11771124
    2. Fatty acid degradation in Escherichia coli. An inducible system for the uptake of fatty acids and further characterization of old mutants. Klein K, et al. Eur J Biochem, 1971 Apr. PMID 4928881
    3. Evidence for a complex of three beta-oxidation enzymes in Escherichia coli: induction and localization. O'Brien WJ, et al. J Bacteriol, 1977 Nov. PMID 334745, Free PMC Article
    4. Regulation of fatty acid degradation in Escherichia coli: analysis by operon fusion. Clark D. J Bacteriol, 1981 Nov. PMID 6271734, Free PMC Article
    5. The beta-oxidation systems of Escherichia coli and Salmonella enterica are not functionally equivalent. Iram SH, et al. J Bacteriol, 2006 Jan. PMID 16385050, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-CoA dehydrogenase
    NP_414756.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      240859..243303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414756.2 acyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414756.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EEN1, A0A8S7I7T9, A0A8T5Z7G2
      Conserved Domains (1) summary
      PRK09463
      Location:42 → 814
      fadE; acyl-CoA dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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