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    mscK potassium dependent, small conductance mechanosensitive channel [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945132, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mscK
    Official Full Name
    potassium dependent, small conductance mechanosensitive channel
    Primary source
    ECOCYC:G6255
    Locus tag
    b0465
    See related
    ASAP:ABE-0001613
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    aefA; ECK0459; kefA
    Summary
    Consistently co-purifies with the degradosome. [More information is available at EcoGene: EG14240]. MscK, the potassium-dependent mechanosensitive (MS) channel of small conductance, is one of four classes of E.coli MS channels. [More information is available at EcoCyc: G6255].
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    Genomic context

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    Sequence:
    NC_000913.3 (486536..489898)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrA Neighboring gene DNA-binding transcriptional repressor AcrR Neighboring gene DUF2496 domain-containing protein YbaM Neighboring gene primosomal replication protein N''

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK. Li C, et al. Mol Microbiol, 2007 Apr. PMID 17493135, Free PMC Article
    2. Characterization of mechanosensitive channels in Escherichia coli cytoplasmic membrane by whole-cell patch clamp recording. Cui C, et al. J Membr Biol, 1995 Mar. PMID 7595939
    3. Effect of mutation of potassium-efflux system, KefA, on mechanosensitive channels in the cytoplasmic membrane of Escherichia coli. Cui C, et al. J Membr Biol, 1996 Mar. PMID 8661775
    4. Identification of N-acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. Linton D, et al. Mol Microbiol, 2002 Jan. PMID 11985725
    5. A patch-clamp study of ion channels of inner and outer membranes and of contact zones of E. coli, fused into giant liposomes. Pressure-activated channels are localized in the inner membrane. Berrier C, et al. FEBS Lett, 1989 Dec 18. PMID 2480919

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular water homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to potassium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium dependent, small conductance mechanosensitive channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      486536..489898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414998.1 potassium dependent, small conductance mechanosensitive channel [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414998.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3P5DMK2, A0AAN5ZHS3
      Conserved Domains (1) summary
      PRK11281
      Location:7 → 1120
      PRK11281; mechanosensitive channel MscK
    Nucleotide Protein
    Heading Accession and Version

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