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    nagA N-acetylglucosamine-6-phosphate deacetylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945289, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nagA
    Official Full Name
    N-acetylglucosamine-6-phosphate deacetylase
    Primary source
    ECOCYC:EG10632
    Locus tag
    b0677
    See related
    ASAP:ABE-0002301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0665
    Summary
    Mg(2+) stimulon-PhoPQ regulon. [More information is available at EcoGene: EG10632]. N-acetylglucosamine-6-phosphate deacetylase catalyzes the first cytoplasmic reaction in the metabolism of N-acetyl-D-glucosamine. [More information is available at EcoCyc: EG10632].
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    Genomic context

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    Sequence:
    NC_000913.3 (701603..702751, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UMP phosphatase Neighboring gene DNA-binding transcriptional dual regulator NagC Neighboring gene glucosamine-6-phosphate deaminase Neighboring gene N-acetylglucosamine-specific PTS enzyme IIABC component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of N-acetylglucosamine-6-phosphate deacetylase apoenzyme from Escherichia coli. Ferreira FM, et al. J Mol Biol, 2006 Jun 2. PMID 16630633
    2. N-acetylglucosamine-6-phosphate deacetylase from Escherichia coli: purification and molecular and kinetic characterization. Souza JM, et al. Arch Biochem Biophys, 1997 Apr 15. PMID 9143339
    3. Tight binding inhibitors of N-acyl amino sugar and N-acyl amino acid deacetylases. Xu C, et al. J Am Chem Soc, 2006 Apr 5. PMID 16568996
    4. Mutations affecting amino sugar metabolism in Escherichia coli K-12. Holmes RP, et al. J Bacteriol, 1972 Jul. PMID 4591481, Free PMC Article
    5. The purification and properties of N-acetylglucosamine 6-phosphate deacetylase from Escherichia coli. White RJ, et al. Biochem J, 1967 Oct. PMID 4861885, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-phosphate deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylglucosamine-6-phosphate deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within N-acetylglucosamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within N-acetylneuraminate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino sugar metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylglucosamine-6-phosphate deacetylase
    NP_415203.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      701603..702751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415203.1 N-acetylglucosamine-6-phosphate deacetylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415203.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MAW2, A0A775UR07, A0A8S7JRP6
      Conserved Domains (1) summary
      PRK11170
      Location:1 → 382
      nagA; N-acetylglucosamine-6-phosphate deacetylase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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