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    moaC cyclic pyranopterin monophosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945397, updated on 3-Dec-2024

    Summary

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    Official Symbol
    moaC
    Official Full Name
    cyclic pyranopterin monophosphate synthase
    Primary source
    ECOCYC:EG11666
    Locus tag
    b0783
    See related
    ASAP:ABE-0002673
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    chlA3; ECK0772
    Summary
    Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other them for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11666].
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    Genomic context

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    Sequence:
    NC_000913.3 (818570..819055)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene GTP 3',8'-cyclase Neighboring gene protein MoaB Neighboring gene molybdopterin synthase sulfur carrier subunit Neighboring gene molybdopterin synthase catalytic subunit Neighboring gene Bax1-I family protein YbhL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue. Hover BM, et al. Biochemistry, 2015 Dec 15. PMID 26575208, Free PMC Article
    2. Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC. Wuebbens MM, et al. Structure, 2000 Jul 15. PMID 10903949
    3. Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. Hover BM, et al. Proc Natl Acad Sci U S A, 2015 May 19. PMID 25941396, Free PMC Article
    4. Assembly reflects evolution of protein complexes. Levy ED, et al. Nature, 2008 Jun 26. PMID 18563089, Free PMC Article
    5. Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors. Rieder C, et al. Eur J Biochem, 1998 Jul 1. PMID 9692897

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MS analysis of MoaC treated with 3',8-cH2GMP[CH2]PP provided strong evidence that compound Y forms a tight complex with MoaC likely through a covalent linkage.
      Title: Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Molecular genetic analysis of the moa operon of Escherichia coli K-12 required for molybdenum cofactor biosynthesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cyclic pyranopterin monophosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic pyranopterin monophosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic pyranopterin monophosphate synthase
    NP_415304.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      818570..819055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415304.1 cyclic pyranopterin monophosphate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415304.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3I887, A0AAJ3P0B5
      Conserved Domains (1) summary
      PRK09364
      Location:1 → 159
      moaC; cyclic pyranopterin monophosphate synthase MoaC
    Nucleotide Protein
    Heading Accession and Version

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