pncB nicotinate phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: pncB
Official Full Name: nicotinate phosphoribosyltransferase
Primary source: ECOCYC:EG10742
Locus tag: b0931
See related: ASAP:ABE-0003167
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0922
Summary: Nicotinate phosphoribosyltransferase (NAPRTase) mediates the formation of nicotinate mononucleotide from exogenous nicotinate and PRPP. [More information is available at EcoCyc: EG10742].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Significant impairment of lysogenization and lytic development of Shiga toxin-converting (Stx) bacteriophages (Phi24B, 933W, P22, P27 and P32) is demonstrated in host cells with a mutant pcnB gene.
Title: Defects in RNA polyadenylation impair both lysogenization by and lytic development of Shiga toxin-converting bacteriophages.
N-terminus verified by Edman degradation on mature peptide
Title: Variation of cofactor levels in Escherichia coli. Sequence analysis and expression of the pncB gene encoding nicotinic acid phosphoribosyltransferase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity, forming carbon-nitrogen bonds	IDA Inferred from Direct Assay more info	PubMed
enables nicotinate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NAD biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in NAD salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_415451.1

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The following sections contain reference sequences that belong to a specific genome build. Explain