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    trpC fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945519, updated on 3-Dec-2024

    Summary

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    Official Symbol
    trpC
    Official Full Name
    fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
    Primary source
    ECOCYC:EG11026
    Locus tag
    b1262
    See related
    ASAP:ABE-0004238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1256; trpCF; trpF
    Summary
    The N-terminal synthase is the TrpC domain and the C-terminal isomerase domain is the TrpF domain. [More information is available at EcoGene: EG11026]. Bifunctional phosphoribosylanthranilate isomerase / indole-3-glycerol phosphate synthase (TrpC) carries out the third and fourth steps in the tryptophan biosynthesis pathway. [More information is available at EcoCyc: EG11026].
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    Genomic context

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    Sequence:
    NC_000913.3 (1318427..1319788, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stress-induced bacterial acidophilic repeat motifs-containing protein YciG Neighboring gene tryptophan synthase subunit alpha Neighboring gene tryptophan synthase subunit beta Neighboring gene anthranilate synthase subunit TrpD Neighboring gene anthranilate synthase subunit TrpE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Indoleglycerol phosphate synthase-phosphoribosyl anthranilate isomerase: comparison of the bifunctional enzyme from Escherichia coli with engineered monofunctional domains. Eberhard M, et al. Biochemistry, 1995 Apr 25. PMID 7727400
    2. Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from Escherichia coli refined at 2.0 A resolution. Wilmanns M, et al. J Mol Biol, 1992 Jan 20. PMID 1738159
    3. Crystallization and structure solution at 4 A resolution of the recombinant synthase domain of N-(5'-phosphoribosyl)anthranilate isomerase:indole-3-glycerol-phosphate synthase from Escherichia coli complexed to a substrate analogue. Wilmanns M, et al. Protein Eng, 1990 Jan. PMID 2184433
    4. Structure of the trpC cistron specifying indoleglycerol phosphate synthetase, and its localization in the tryptophan operon of Escherichia coli. Smith OH. Genetics, 1967 Sep. PMID 4865047, Free PMC Article
    5. N-(5'-phosphoribosyl)anthranilate isomerase-indol-3-ylglycerol phosphate synthetase of tryptophan biosynthesis. Relationship between the two activities of the enzyme from Escherichia coli. Creighton TE. Biochem J, 1970 Dec. PMID 4924490, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the unfolding pathway of ePRAI, a (beta/alpha)8-barrel protein, by molecular dynamics simulations
      Title: A detailed unfolding pathway of a (beta/alpha)8-barrel protein as studied by molecular dynamics simulations.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables indole-3-glycerol-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables indole-3-glycerol-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables indole-3-glycerol-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylanthranilate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alpha-amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in indolalkylamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tryptophan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
    NP_415778.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1318427..1319788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415778.3 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415778.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X5H0P3, A0AAE9TQE7, Q2XN48
      Conserved Domains (1) summary
      PRK09427
      Location:1 → 453
      PRK09427; bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF
    Nucleotide Protein
    Heading Accession and Version

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