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    puuA glutamate-putrescine ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946202, updated on 3-Dec-2024

    Summary

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    Official Symbol
    puuA
    Official Full Name
    glutamate-putrescine ligase
    Primary source
    ECOCYC:G6644
    Locus tag
    b1297
    See related
    ASAP:ABE-0004365
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1292; ycjK
    Summary
    puuA is transiently induced after a cold shock. [More information is available at EcoGene: EG13908]. Glutamate-putrescine ligase is the first enzyme in the primary putrescine utilization pathway of Escherichia coli . [More information is available at EcoCyc: G6644].
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    Genomic context

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    Sequence:
    NC_000913.3 (1359490..1360908, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2543 domain-containing protein YmjA Neighboring gene putrescine:H(+) symporter PuuP Neighboring gene protein YmjE Neighboring gene gamma-glutamyl-gamma-aminobutyrate hydrolase Neighboring gene DNA-binding transcriptional repressor PuuR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. gamma-Glutamylputrescine synthetase in the putrescine utilization pathway of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2008 Jul 18. PMID 18495664
    2. Changes in Escherichia coli transcriptome during acclimatization at low temperature. Polissi A, et al. Res Microbiol, 2003 Oct. PMID 14527658
    3. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2005 Feb 11. PMID 15590624
    4. Escherichia coli transcriptome dynamics during the transition from anaerobic to aerobic conditions. Partridge JD, et al. J Biol Chem, 2006 Sep 22. PMID 16857675
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-putrescine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-putrescine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-nitrogen bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within putrescine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate-putrescine ligase
    NP_415813.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1359490..1360908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415813.4 glutamate-putrescine ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415813.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376ZWM8, A0A5B9AK13
      Conserved Domains (1) summary
      COG0174
      Location:23 → 471
      GlnA; Glutamine synthetase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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