U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    paaF putative 2,3-dehydroadipyl-CoA hydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946011, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    paaF
    Official Full Name
    putative 2,3-dehydroadipyl-CoA hydratase
    Primary source
    ECOCYC:G6714
    Locus tag
    b1393
    See related
    ASAP:ABE-0004659
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1390; ydbR; ydbS
    Summary
    paaF mutants accumulate delta3-dehydroadipate. [More information is available at EcoGene: EG13740]. PaaF is a putative enoyl-CoA hydratase/isomerase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6714].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1457497..1458264)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, structural subunit Neighboring gene phenylacetate degradation protein Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex. Grishin AM, et al. J Biol Chem, 2012 Nov 2. PMID 22961985, Free PMC Article
    2. New FadB homologous enzymes and their use in enhanced biosynthesis of medium-chain-length polyhydroxyalkanoates in FadB mutant Escherichia coli. Park SJ, et al. Biotechnol Bioeng, 2004 Jun 20. PMID 15137080
    3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    4. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Teufel R, et al. Proc Natl Acad Sci U S A, 2010 Aug 10. PMID 20660314, Free PMC Article
    5. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the PaaFG complex has a four-layered structure composed of homotrimeric discs of PaaF and PaaG.
      Title: Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-CoA hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enoyl-CoA hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative 2,3-dehydroadipyl-CoA hydratase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1457497..1458264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415911.1 putative 2,3-dehydroadipyl-CoA hydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415911.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A776LQI6
      Conserved Domains (1) summary
      PRK09674
      Location:1 → 255
      PRK09674; enoyl-CoA hydratase-isomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.