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    paaJ beta-ketoadipyl-CoA thiolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946121, updated on 17-Dec-2024

    Summary

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    Official Symbol
    paaJ
    Official Full Name
    beta-ketoadipyl-CoA thiolase
    Primary source
    ECOCYC:G6718
    Locus tag
    b1397
    See related
    ASAP:ABE-0004668
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1394; ydbW
    Summary
    PaaJ is a -ketoadipyl-CoA thiolase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6718].
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    Genomic context

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    Sequence:
    NC_000913.3 (1460893..1462098)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene phenylacetate-CoA ligase Neighboring gene DNA-binding transcriptional repressor PaaX Neighboring gene 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the last step of the aerobic phenylacetic acid degradation pathway. Nogales J, et al. Microbiology (Reading), 2007 Feb. PMID 17259607
    2. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    3. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
    4. Proteome analysis of Escherichia coli using high-performance liquid chromatography and Fourier transform ion cyclotron resonance mass spectrometry. Ihling C, et al. Proteomics, 2005 May. PMID 15852340
    5. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-oxoadipyl-CoA thiolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-oxoadipyl-CoA thiolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA C-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3,4-dihydroxybenzoate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylacetate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-ketoadipyl-CoA thiolase
    NP_415915.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1460893..1462098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415915.1 beta-ketoadipyl-CoA thiolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415915.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1X5A2
      Conserved Domains (1) summary
      PRK09050
      Location:1 → 401
      PRK09050; beta-ketoadipyl CoA thiolase; Validated
    Nucleotide Protein
    Heading Accession and Version

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