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    hrpA ATP-dependent 3'->5' RNA helicase HrpA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948444, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hrpA
    Official Full Name
    ATP-dependent 3'->5' RNA helicase HrpA
    Primary source
    ECOCYC:G6732
    Locus tag
    b1413
    See related
    ASAP:ABE-0004718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1406
    Summary
    HrpA has sequence similarity to DEAH-box RNA helicases . [More information is available at EcoCyc: G6732].
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    Genomic context

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    Sequence:
    NC_000913.3 (1483061..1486963)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphatase domain-containing protein YnbD Neighboring gene FMN dependent NADH:quinone oxidoreductase Neighboring gene DUF218 domain-containing protein YdcF Neighboring gene aldehyde dehydrogenase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition. Xin BG, et al. Nucleic Acids Res, 2024 Apr 12. PMID 38412313, Free PMC Article
    2. Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility. Grass LM, et al. Proc Natl Acad Sci U S A, 2021 Jul 27. PMID 34290142, Free PMC Article
    3. Overexpression and purification of tagged Escherichia coli proteins using a chromosomal knock-in strategy. Jain C. Protein Expr Purif, 2006 Apr. PMID 16139517
    4. Cloning and characterization of the hrpA gene in the terC region of Escherichia coli that is highly similar to the DEAH family RNA helicase genes of Saccharomyces cerevisiae. Moriya H, et al. Nucleic Acids Res, 1995 Feb 25. PMID 7899078, Free PMC Article
    5. HrpA, a DEAH-box RNA helicase, is involved in mRNA processing of a fimbrial operon in Escherichia coli. Koo JT, et al. Mol Microbiol, 2004 Jun. PMID 15186427

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
      Title: Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent 3'->5' RNA helicase HrpA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1483061..1486963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415931.4 ATP-dependent 3'->5' RNA helicase HrpA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415931.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7RER0
      Conserved Domains (1) summary
      PRK11131
      Location:5 → 1298
      PRK11131; ATP-dependent RNA helicase HrpA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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