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    rfbB dTDP-glucose 4,6-dehydratase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945276, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rfbB
    Official Full Name
    dTDP-glucose 4,6-dehydratase 1
    Primary source
    ECOCYC:EG12412
    Locus tag
    b2041
    See related
    ASAP:ABE-0006766
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2035; rmlB; som
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    Genomic context

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    Sequence:
    NC_000913.3 (2111976..2113061, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene polyisoprenol-linked O16-antigen repeat unit flippase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1 Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene UTP:glucose-1-phosphate uridylyltransferase, low activity Neighboring gene putative colanic acid biosynthesis protein WcaM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Function of rmlB in the pathogenic Escherichia coli 44277 (O2: k1)]. Ding W, et al. Wei Sheng Wu Xue Bao, 2011 Sep. PMID 22126071
    2. Mechanistic studies of the biosynthesis of 3,6-dideoxyhexoses in Yersinia pseudotuberculosis. Purification and stereochemical analysis of CDP-D-glucose oxidoreductase. Yu Y, et al. J Biol Chem, 1992 Mar 25. PMID 1556102
    3. Biological mechanisms involved in the formation of deoxy sugars. V. Isolation and crystallization of thymidine diphosphate-D-glucose oxidoreductase from Escherichia coli B. Wang SF, et al. J Biol Chem, 1969 Jul 10. PMID 4307450
    4. Biological mechanisms involved in the formation of deoxysugars. VI. Role and function of enzyme-bound nicotinamide adenine dinucleotide in thymidine diphosphate D-glucose oxidoreductase. Wang SF, et al. J Biol Chem, 1970 Jan 10. PMID 4312478
    5. The mechanism of 6-deoxyhexose synthesis. V. The relation of pyridine nucleotide to the structure of the deoxythymidine diphosphate-glucose oxidoreductase. Zarkowsky H, et al. J Biol Chem, 1970 Dec 25. PMID 4320607

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RmlB has the activity of dTDP-D-glucose 4,6-dehydratase but it is not essential for the synthesis of L-rhamnose.
      Title: [Function of rmlB in the pathogenic Escherichia coli 44277 (O2: k1)].
    2. Results showed a reproducible and clear cut classification with molecular polymorphism of rfb gene cluster and flagella gene fliC.
      Title: Molecular typing of Escherichia coli strains isolated from food in Casablanca (Morocco).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dTDP-glucose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dTDP-glucose 4,6-dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dTDP-glucose 4,6-dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dTDP-glucose 4,6-dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in O antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTDP-rhamnose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nucleotide-sugar biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-sugar metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dTDP-glucose 4,6-dehydratase 1
    NP_416545.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2111976..2113061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416545.1 dTDP-glucose 4,6-dehydratase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416545.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0A8J6R4
      Conserved Domains (1) summary
      PRK10084
      Location:1 → 352
      PRK10084; dTDP-glucose 4,6 dehydratase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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