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    dedD cell division protein DedD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944971, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dedD
    Official Full Name
    cell division protein DedD
    Primary source
    ECOCYC:EG10218
    Locus tag
    b2314
    See related
    ASAP:ABE-0007643
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2308
    Summary
    DedD has similarity to a protein from Pseudomonas aeruginosa . [More information is available at EcoCyc: EG10218].
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    Genomic context

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    Sequence:
    NC_000913.3 (2431022..2431684, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene amidophosphoribosyltransferase Neighboring gene colicin V production protein Neighboring gene bifunctional folylpolyglutamate synthetase/dihydrofolate synthetase Neighboring gene acetyl-CoA carboxyltransferase subunit beta Neighboring gene DedA family protein DedA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the DedD Protein in Escherichia coli Cell Constriction. Liu B, et al. J Bacteriol, 2019 Apr 15. PMID 30692172, Free PMC Article
    2. A requirement for cell elongation protein RodZ and cell division proteins FtsN and DedD to maintain the small rod morphology of Escherichia coli at growth temperatures near 8°C. Porter T, et al. J Gen Appl Microbiol, 2016 Sep 12. PMID 27477251
    3. SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli. Pazos M, et al. mBio, 2020 Nov 3. PMID 33144379, Free PMC Article
    4. Self-enhanced accumulation of FtsN at Division Sites and Roles for Other Proteins with a SPOR domain (DamX, DedD, and RlpA) in Escherichia coli cell constriction. Gerding MA, et al. J Bacteriol, 2009 Dec. PMID 19684127, Free PMC Article
    5. Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA. Arends SJ, et al. J Bacteriol, 2010 Jan. PMID 19880599, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Like FtsN, DedD promotes cell fission by stimulating septal peptidoglycan synthesis, as well as by providing positive feedback to the septal peptidoglycan loop.
      Title: Roles of the DedD Protein in Escherichia coli Cell Constriction.
    2. The data indicate the cellular requirement of both FtsN and DedD for septation as well as RodZ for cell elongation to maintain the small rod morphology at temperatures near 8 degrees C.
      Title: A requirement for cell elongation protein RodZ and cell division proteins FtsN and DedD to maintain the small rod morphology of Escherichia coli at growth temperatures near 8°C.
    3. The loss of DamX or DedD either alone or in combination with mutations in genes encoding other division proteins resulted in a variety of division phenotypes, demonstrating that DamX and DedD participate in cytokinesis.
      Title: Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA.
    4. Further analyses showed that DamX and, especially, DedD are genuine division proteins that contribute significantly to the cell constriction process.
      Title: Self-enhanced accumulation of FtsN at Division Sites and Roles for Other Proteins with a SPOR domain (DamX, DedD, and RlpA) in Escherichia coli cell constriction.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokinetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytokinetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell septum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell septum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division protein DedD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2431022..2431684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416817.2 cell division protein DedD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416817.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WYF3
      Conserved Domains (1) summary
      PRK11633
      Location:1 → 220
      PRK11633; cell division protein DedD; Provisional
    Nucleotide Protein
    Heading Accession and Version

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